Atopic dermatitis (AD) is a chronic, pruritus skin disease, which can affect both adults and children. It is more common in children and is difficult to cure in a short time. Due to limitations of drug selection in infants and children, there are great challenges in the treatment of pediatric AD. In addition to traditional treatments such as topical corticosteroids and calcineurin inhibitors, small-molecule inhibitors and biological agents targeting specific inflammatory pathway in the pathogenesis of AD have been gradually in clinical use. This paper reviews therapies currently available to pediatric AD.