Objective　To explore the risk factors in the prognosis of neonatal capillary leak syndrome (CLS). Methods From October 2010 to July 2019, newborns who were clearly diagnosed with CLS and whose admission age was <28 days were selected as the study subjects. The clinical data of newborns in the survival group and the death group were retrospectively analyzed and the risk factors in the prognosis of CLS were analyzed. Results　In a total of 66 CLS newborns included, 46 (69.7%) survived and 20 (30.3%) died. Compared with the death group, the birth weight of the survival group was higher and the proportion of children with low birth weight was lower, and the differences were statistically significant (P<0.05). The prevalence of pulmonary hemorrhage, gastrointestinal hemorrhage, hyperglycemia and hyperkalemia in the survival group was lower than those in the death group, and the differences were statistically significant (all P<0.05). Logistic regression analysis showed that pulmonary hemorrhage (OR=8.20, 95%CI: 2.29~29.40, P=0.001) significantly increased the mortality of children with CLS. Conclusion　Pulmonary hemorrhage is an independent risk factor for the prognosis of CLS.