Objective　To investigate the correlation between intrauterine intervention and clinical features and outcomes of non-immune hydrops fetalis (NIHF). Methods　Clinical data from 33 neonates with NIHF delivered in the Eastern Campus of Shanghai First Maternal and Infant Hospital from January 2014 to December 2016 were summarized. The relevant data of mothers and newborns were collected, and analyzed according to their status as survived (the survival group) or not (the death group). Regression analysis was carried out. Results　There was significant difference in these factors including birth weight, chromosome abnormality, Apgar scores of 1 mins and 5 mins (P<0.05) between death group and survival group. There was no significant difference in the rest factors (P>0.05). The incidence of maternal complications (P<0.05) and intrauterine intervention (P <0.01) in the neonatal intubation group were higher than that in the neonatal non-intubation group, differences were significant. Intrauterine intervention is an independent factor affecting the resuscitation rate in the delivery room (OR=0.065, 95%CI: 0.0110.407). The 1 min Apgar score was a risk factor of mortality for NIHF (OR=1.745, 95% CI: 1.201-2.534). The lower Apgar score and birth weight, the higher the mortality. Conclusions　Intrauterine intervention during pregnancy and the need for resuscitation during delivery are related factors affecting the outcome of NIHF.