A case of pneumocystis pneumonia in infants diagnosed by next generation sequencing of BALF and literature review

  • 朱其国,袁林,周峻荔,等
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  • 1.Respiratory Department of Xiamen Children's Hospital, Children’s Hospital of Fudan University Xiamen Branch, Xiamen 361006, Fujian, China; 2. Respiratory Department of Children’s Hospital of Fudan University, Shanghai 201102, China

Online published: 2020-06-02

Abstract

 Objective To investigate the etiology, clinical manifestations, etiological diagnosis and treatment of pneumocystis pneumonia. Methods The clinical data of a child with pneumocystis pneumonia were retrospectively analyzed. Results A male infant, aged 2 months and 20 days, presented with chronic cough, shortness of breath, irritability, and hypoxemia. Pulmonary imaging showed diffuse infiltration of both lungs. The metagenomic next-generation sequencing of bronchoalveolar lavage fluid by bronchoscope confirmed pneumocystis infection. Clinical symptoms of the patient disappeared and exudation of lung CT absorbed after treatment with trimethoprim-sulfamethoxazole. Conclusion Infants should be alerted to pneumocystis pneumonia when having recurrent cough, shortness of breath, hypoxemia and diffuse infiltration in both lungs. Metagenomic next-generation sequencing with bronchoscopic alveolar lavage fluid is a better method for pathogenic diagnosis of pneumocystis pneumonia.

Cite this article

朱其国,袁林,周峻荔,等 . A case of pneumocystis pneumonia in infants diagnosed by next generation sequencing of BALF and literature review[J]. Journal of Clinical Pediatrics, 2020 , 38(5) : 370 . DOI: 10.3969/j.issn.1000-3606.2020.05.014

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