Objective? To?explore?the?pertussis?antibody?levels?of?mothers?of?different?ages?and?their?newborns.? Methods Enzyme-linked?immunosorbent?assay?was?used?to?detect?the?pertussis?antibody?levels?in?the?peripheral?blood?of?100? pairs?of?healthy?mothers?of?different?ages?and?the?umbilical?cord?blood?(newborn?side)?of?their?newborns.?Results The median levels?of?pertussis?IgG?antibodies?in?women?born?in?the?1970s,?1980s?and?1990s?were?7.99?IU/mL,?5.00?IU/mL?and?5.71?IU/ mL,?respectively,?and?the?difference?among?the?three?groups?were?statistically?significant?(P<0.05).?Serum?pertussis?IgG?antibody? was?negative?in?97%?of?the?mothers?and?negative?in?92%?of?the?newborns.?There?was?a?positive?correlation?between?maternal? serum?pertussis?IgG?antibody?levels?and?neonatal?umbilical?cord?blood?pertussis?IgG?antibody?levels?(r=0.76， P<0.001).? Conclusion? Current?maternal?pertussis?antibodies?cannot?protect?women?from?pertussis?infection,?and?the?protective?effect?of?fetal? antibodies?obtained?from?the?mother?is?weak.?Further?adjustment?of?immunization?strategies?to?prevent?pertussis?may?be?considered.?