Objective To summarize and analyze the epidemiology and clinical manifestations of a typical family cluster novel coronavirus ( 2019 -nCoV) infection. Methods In order to explore the source of infection, the travel trajectory were tracked for nine members from three generations of a closely related family who got typical 2019 -nCoV cluster infection after they participated in the cruise tour. According to the principles of diagnosis and treatment of 2019 -nCoV infection, the characteristics of the confirmed cases and their correlation with age were analyzed and compared. Results The family consisted of 9 people ( 6 adults and 3 children). The whole family of 9 members ( 6 adults, 3 children) started the cruise in a highrisk epidemic area in Wuhan City, Hubei Province. After participating in cruise tourism, the oldest grandfather ( 71 -year-old) developed the disease first. Eight members ( 88. 9%) were subsequently diagnosed with 2019 -nCoV infection. All six adults and two in three children ( 66 . 7%) were diagnosed. The incubation period of all confirmed cases was significantly longer than 14 days, up to 18 - 24 days. The severity of the disease and the absolute lymphocyte count (ALC) were associated with age. After active treatment, all cases were cured. Conclusion Having a history of living or exposure in an epidemic area and the characteristics of cluster infection still important epidemiological diagnostic basis for 2019- nCoV infection.