Research progress in human milk active ingredient-osteopontin

  • ZHU Jing
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  • 1 .Beijing Institute of Nutritional Sources, Beijing Academy of Science and Technology, Beijing 100069 , China; 2 . Department of Child and Adolescent Hygiene and Maternal and Child Health, School of Public Health, Nanjing Medical University, Nanjing 211166 , Jiangsu, China; 3 . Department of Immunology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

Online published: 2021-04-15

Abstract

Osteopontin (OPN) is a highly phosphorylated acidic protein with O-glycosylation modification and has attracted much attention in recent years. According to the distribution of OPN in the body, it can be divided into secreted OPN and intracellular OPN. It can be synthesized or secreted by a variety of tissues and cells in the body, and widely exists in bone, kidney, brain, muscle and other tissues and cells. Recent studies have found that secretory OPN is high in breast milk, especially in colostrum, and that secretory OPN plays an important role in intestinal growth, immune regulation and nervous system development in early life. This article reviews the research progress in the effects of OPN in milk on early life growth and health.

Cite this article

ZHU Jing . Research progress in human milk active ingredient-osteopontin[J]. Journal of Clinical Pediatrics, 2021 , 39(4) : 313 . DOI: 10.3969/j.issn.1000-3606.2021.04.019

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