Research progress of granzyme A and its related diseases

  • NIU Rongwei
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  • 1.Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120 , Guangdong, China; 2 .Guangdong Academy of Medical Sciences, Department of Pediatrics, Guangdong Provincial People’s Hospital, Guangzhou 510080 , Guangdong, China

Online published: 2021-09-03

Abstract

Granzyme A (GzmA) is a serine protease secreted by natural killer cells and cytotoxic T lymphocytes. It can regulate the body's immune defense by inducing apoptosis and pyrolysis, and it can also kill bacteria and parasites that invade the host cells to maintain body homeostasis. Recent studies have found that GzmA influences the pathogenesis and development of tuberculosis, sepsis, and rheumatoid arthritis by regulating the release of IL- 6 and TNF-伪, and also it can activate pSTAT 3 to promote the development of intestinal inflammation and colorectal cancer. This article reviews the characteristics and functions of GzmA, as well as its role in inflammatory process, autoimmune diseases and tumors.

Cite this article

NIU Rongwei . Research progress of granzyme A and its related diseases[J]. Journal of Clinical Pediatrics, 2021 , 39(9) : 711 . DOI: 10.3969/j.issn.1000-3606.2021.09.017

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