Objective To investigate the clinical characteristics of immune thrombocytopenia (ITP) children with myocardial injury. Methods Newly diagnosed ITP children hospitalized in Wuhan Children's Hospital from December 2018 to April 2020 were retrospectively analyzed. According to the complication, children were divided into the non-myocardial injury group and myocardial injury group. The clinical characteristics, laboratory examination and prognosis of the two groups were compared. Results In this study, 360 newly diagnosed ITP children were analyzed, including 240 boys and 120 girls, with a median age of 3.0 (2.0~6.0) years. Of the 360 children, 294 were in the non-myocardial injury group and 66 were in myocardial injury group. Compared with the non-myocardial injury group, levels of CK, CK-MB and LDH-L in myocardial injury group were higher, the proportions of girls and younger children were higher, the values of thromboelastogram-maximal amplitude were larger, the proportions of children with PLT <10×10 ⁹/L / bleeding score >3 were lower, the counts of platelet, white blood cells, CD8 ⁺T cells and NK cells were higher, the levels of IgE were lower. These differences were statistically significant (P<0.05). Log-rank analysis showed that platelet recovery of the myocardial injury group was slower than the non-myocardial injury group after treatment (P<0.001). Conclusion It is not rare for ITP children with myocardial injury. Although platelet recovery is slower at initial diagnosis, myocardial injury does not promote the progression of newly diagnosed ITP to persistent ITP.