Journal of Clinical Pediatrics >
Update on the progress in diagnosis and treatment of benign epilepsy of childhood with centrotemporal spikes
Received date: 2022-01-10
Online published: 2022-03-09
Benign epilepsy of childhood with centrotemporal spikes (BECT) is the commonest focal epilepsy syndrome in children. The pathogenesis of BECTS involves the interaction of complex polygenes and environmental factors, presenting a pattern of multifactorial inheritance. BECTS can evolve into atypical BECTS, both of which can be combined with electrical status epilepticus during slow wave sleep (ESES). The treatment of BECTS requires consideration of multiple factors and individualized risk-benefit assessment to determine the best treatment regimen. Early recognition and diagnosis of BECTS comorbid cognitive impairment should be emphasized. Attention deficit hyperactivity disorder (ADHD) is the commonest childhood psychobehavioral comorbidity of BECTS. Formal treatment of BECTS comorbid ADHD should be initiated as soon as possible. There are still many problems and challenges in the clinical diagnosis and treatment of BECTS. This article will review the recent progress in the diagnosis and treatment of BECTS, aiming to provide reference for the clinical diagnosis and treatment of BECTS and improve the life quality of children with BECTS.
Yuying FAN , Xueyan LIU , Hua WANG . Update on the progress in diagnosis and treatment of benign epilepsy of childhood with centrotemporal spikes[J]. Journal of Clinical Pediatrics, 2022 , 40(3) : 177 -183 . DOI: 10.12372/jcp.2022.22e051
[1] | Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology[J]. Epilepsia, 2017, 58(4): 512-521. |
[2] | 刘晓燕. 临床脑电图学[M]. 2 版. 北京: 人民卫生出版社, 2017: 335. |
[3] | Dryzalowski P, Jozwiak S, Franckiewicz M, et al. Benign epilepsy with centrotemporal spikes - current concepts of diagnosis and treatment[J]. Neurol Neurochir Pol, 2018, 52(6): 677-689. |
[4] | Wickens S, Bowden SC, D'Souza W. Cognitive functioning in children with self-limited epilepsy with centrotemporal spikes: A systematic review and meta-analysis[J]. Epilepsia, 2017, 58(10): 1673-1685. |
[5] | Ramos-Lizana J, Martínez-Espinosa G, Aguilera-López P, et al. Probability of remission of the main epileptic syndromes in childhood[J]. J Child Neurol, 2022, 37(1): 89-97. |
[6] | Xiong W, Zhou D. Progress in unraveling the genetic etiology of rolandic epilepsy[J]. Seizure, 2017, 47: 99-104. |
[7] | Chen J, Zheng G, Guo H, et al. Epileptic negative myoclonus as the first and only symptom in a challenging diagnosis of benign epilepsy with centrotemporal spikes[J]. Child Neurol Open, 2017, 4: 1-6. |
[8] | Yang L, Su Q, Xu N, et al. Continuous epileptic negative myoclonus as the first seizure type in atypical benign epilepsy with centrotemporal spikes[J]. Medicine (Baltimore), 2020, 99(44): e22965. |
[9] | Gong P, Xue J, Qian P, et al. Epileptic negative myoclonus restricted to lower limbs in benign childhood focal epilepsy with vertex spikes[J]. Eur J Neurol, 2019, 26(10): 1318-1326. |
[10] | 龚潘, 薛姣, 钱萍, 等. 以对应于中线放电的癫痫性负性肌阵挛起病的儿童癫痫电临床特点[J]. 中华儿科杂志, 2019, 57(12): 943-949. |
[11] | 张静, 张月华, 刘晓燕, 等. 癫痫的ILAE分类:ILAE 委员会关于分类和术语的意见书[J]. 癫痫杂志, 2018, 4(6): 517-524. |
[12] | 段亦然, 高瑜, 李铭, 等. 特发性伴中央颞区棘波的癫痫谱系疾病的遗传学研究进展[J]. 中华神经科杂志, 2019, 52(1): 55-61. |
[13] | Shi XY, Wang G, Li T, et al. Identification of susceptibility variants to benign childhood epilepsy with centro-temporal spikes (BECTS) in Chinese Han population[J]. EBioMedicine, 2020, 57: 102840. |
[14] | Neng X, Xiao M, Yuanlu C, et al. Novel variant in CHRNA4 with benign childhood epilepsy with centro-temporal spikes and contribution to precise medicine[J]. Mol Genet Genomic Med, 2020, 8(7): e1264. |
[15] | Duan Y, Leng X, Liu C, et al. The correlation of ELP4-PAX6 with Rolandic spike sources in idiopathic Rolandic epilepsy syndromes[J]. Front Neurol, 2021, 12: 643964. |
[16] | Ma MG, Liu XR, Wu Y, et al. RYR2 mutations are associated with benign epilepsy of childhood with centrotemporal spikes with or without arrhythmia[J]. Front Neurosci, 2021, 15: 629610. |
[17] | Liu Z, Ye X, Zhang J, et al. Biallelic ADGRV1 variants are associated with Rolandic epilepsy[J]. Neurol Sci, 2022, 43(2): 1365-1374. |
[18] | Mohandas N, Loke YJ, Mackenzie L, et al. Deciphering the role of epigenetics in self-limited epilepsy with centrotemporal spikes[J]. Epilepsy Res, 2019, 156: 106163. |
[19] | Devarbhavi H. Rolandic epilepsy as a heralding mani-festation of Wilson disease in a 6-year-old girl[J]. J Clin Exp Hepatol, 2020, 10(6): 633-635. |
[20] | Liu MJ, Su XJ, Md XS, et al. Clinical features of benign epilepsy of childhood with centrotemporal spikes in Chinese children[J]. Medicine (Baltimore), 2017, 96(4): e5623. |
[21] | An O, Nagae LM, Winesett SP. A self-limited childhood epilepsy as co-incidental in cerebral palsy[J]. Int Med Case Rep J, 2021, 14: 509-517. |
[22] | Gu W, Chen J, Tian W, et al. Outcome analysis of children with rolandic discharges on EEG: A real-world study[J]. Seizure, 2020, 82: 105-108. |
[23] | Klinzing JG, Tashiro L, Ruf S, et al. Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes[J]. Cell Rep Med, 2021, 2(11): 100432. |
[24] | Timofeev I. Just a sound: a non-pharmacological treatment approach in epilepsy[J]. Cell Rep Med, 2021, 2(11): 100451. |
[25] | Zhang K, Yan Y, Su T. Treatment strategies for encephalopathy related to status epilepticus during slow sleep, a narrative review of the literature[J]. Rev Neurosci, 2020, 31(7): 793-802. |
[26] | Zanaboni MP, Varesio C, Pasca L, et al. Systematic review of executive functions in children with self-limited epilepsy with centrotemporal spikes[J]. Epilepsy Behav, 2021, 123: 108254. |
[27] | Ramos IDSS, Coelho CVG, Ribeiro F, et al. Executive functioning in children with self-limited epilepsy with centrotemporal spikes: a systematic review and meta-analysis[J]. Child Neuropsychol, 2022, 28(1): 30-60. |
[28] | Wu L, Yang X, Zhang K, et al. Impairment of eye emotion discrimination in benign childhood epilepsy with centrotemporal spikes: A neuropsychological study[J]. Brain Behav, 2021, 11(6): e02154. |
[29] | Kirby A, Williams N, Koelewijn L, et al. Benign childhood epilepsy with centrotemporal spikes (BECTS) and developmental co-ordination disorder[J]. Epilepsy Behav, 2017, 72: 122-126. |
[30] | Varesio C, Zanaboni MP, Salmin EC, et al. Childhood epilepsy with centrotemporal spikes: clinical and neuropsychological outcomes 5 years after remission[J]. Diagnostics (Basel), 2020, 10(11): 931. |
[31] | 张珺, 孙伟. 儿童良性癫痫伴中央颞区棘波患者的认知损害研究[J]. 癫痫杂志, 2020, 6(2): 93-97. |
[32] | Zhang J, Yang H, Wu D, et al. Electroencephalographic abnormalities are correlated with cognitive deficits in children with benign childhood epilepsy with centrotemporal spikes: a clinical study of 61 cases[J]. Epilepsy Behav, 2020, 106: 107012. |
[33] | Özgen Y, Güngör M, Kutlu M, et al. Clinical and electrophysiological predictors of behavioral disorders in patients with benign childhood epilepsy with centrotemporal spikes[J]. Epilepsy Behav, 2021, 121(Pt A): 108037. |
[34] | Wang P, Li Y, Sun Y, et al. Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: a multi-frequency MEG study[J]. Epilepsy Behav, 2021, 124: 108276. |
[35] | Dai XJ, Liu H, Yang Y, et al. Brain network excitatory/inhibitory imbalance is a biomarker for drug-naive Rolandic epilepsy: a radiomics strategy[J]. Epilepsia, 2021, 62(10): 2426-2438. |
[36] | Huang C, Hu W, Tan G, et al. Clinical and electro-encephalographic features of benign childhood epilepsy with centrotemporal spikes comorbidity with attention-deficit hyperactivity disorder in Southwest China[J]. Epilepsy Behav, 2020, 111: 107240. |
[37] | 韩颖, 张月华, 肖农, 等. 儿童癫痫共患注意缺陷多动障碍诊断治疗的中国专家共识[J]. 癫痫杂志, 2018, 4(4): 281-289. |
[38] | Doumlele K, Friedman D, Buchhalter J, et al. Sudden unexpected death in epilepsy among patients with benign childhood epilepsy with centrotemporal spikes[J]. JAMA Neurol, 2017, 74(6): 645-649. |
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