Epidemiological characteristics and drug resistance analysis of respiratory tract infections in hospitalized children caused by Moraxelle catarrhalis in Suzhou area

Yinyin WU; Liya ZHANG; Yunzhen TAO; Lili HUANG; Wei JI

doi:10.12372/jcp.2022.21e1254

2022 , Vol. 40 >Issue 4: 279 - 283

DOI: https://doi.org/10.12372/jcp.2022.21e1254

Epidemiological characteristics and drug resistance analysis of respiratory tract infections in hospitalized children caused by Moraxelle catarrhalis in Suzhou area

Yinyin WU ,
Liya ZHANG ,
Yunzhen TAO ,
Lili HUANG ,
Wei JI

Expand

1. Department of Comprehensive Internal, Children's Hospital Affiliated to Soochow University, Suzhou 215003, Jiangsu, China
2. Laboratory Medicine, Children's Hospital Affiliated to Soochow University, Suzhou 215003, Jiangsu, China
3. Department of Respiratory Medicine, Children's Hospital Affiliated to Soochow University, Suzhou 215003, Jiangsu, China

Received date: 2021-08-30

Online published: 2022-04-07

Fold

Abstract

Objective To analyze the epidemiological characteristics and drug sensitivity changes of respiratory tract infections in hospitalized children caused by Moraxelle Catarrhalis (MC) in Suzhou area, so as to provide information for the rational use of antibiotics in clinic.Methods The results of bacterial culture in nasopharyngeal secretions of hospitalized children with respiratory tract infection from January 2008 to December 2020 were collected. The children were divided into groups according to age, season and basic diseases. The epidemic characteristics of MC infection were monitored and the changes of MC drug sensitivity were dynamically observed.Results A total of 27 472 specimens of nasopharyngeal secretions from children with respiratory tract infections were collected in the past 13 years, of which 742 specimens were cultured with MC, and the total detection rate of MC was 2.7%. There were significant differences in MC detection rates among different years from 2008 to 2020 (P<0.01), and the detection rate in 2017 was higher. There was significant difference in the detection rate of MC among different age groups (P<0.01). The detection rate was higher in 3-5 years, and lower in >5 years. The difference of MC detection rate among spring, summer, autumn and winter was statistically significant (P<0.01) and the detection rate was higher in autumn and lower in summer. Among 27 472 children, 18.9% had basic diseases. The detection rate of MC in the group with concomitant diseases was 1.8%, lower than that in the group without concomitant diseases (2.9%), and the difference was statistically significant (P<0.01). The results of drug susceptibility tests from 2013 to 2020 were summarized, and it was found that MC was highly sensitive to rifampicin, chloramphenicol, cefotaxime, tetracycline and levofloxacin. The sensitivity rate of drug sensitivity test was statistically significant among 8 years (P<0.05). MC also had high sensitivity rate to amoxicillin and cotrimoxazole.Conclusions The children infected with MC in Suzhou were mainly less than 5 years old. Autumn was the frequent season of onset, and MC had a high sensitivity rate to multiple antibiotics. Amoxicillin is recommended as the first treatment for MC infection of respiratory tract in children.

Key words： Moraxelle Catarrhalis; respiratory tract; child

Cite this article

Yinyin WU , Liya ZHANG , Yunzhen TAO , Lili HUANG , Wei JI . Epidemiological characteristics and drug resistance analysis of respiratory tract infections in hospitalized children caused by Moraxelle catarrhalis in Suzhou area[J]. Journal of Clinical Pediatrics, 2022 , 40(4) : 279 -283 . DOI: 10.12372/jcp.2022.21e1254

References

[1]	Broides A, Dagan R., Greenberg D, et al. Acute otitis media caused by Moraxella catarrhalis: epidemiologic and clinical characteristics[J]. Clin. Infect. Dis, 49(11):1641-1647.
[2]	Khan MA, Northwood JB, Levy F, et al. Bro{beta}-lactamase and antibiotc resistances in a global cross-sectional study of Moraxella catarrhalis from children and adults[J]. J Antimicrob Chemother, 2010, 65(1):91-97.
[3]	Bair KL, Campagnari AA. Moraxella catarrhalis promotes stable polymicrobial biofilms with the major otopathogens[J]. Front Microbiol, 2020, 10:3006.
[4]	车大钿, 张育才. 卡他莫拉菌研究进展[J]. 国际儿科学杂志, 2010, 37(2):206-208.
[5]	江载芳, 申昆玲, 沈颖, 等. 诸福棠实用儿科学[M]. 8 版.北京: 人民卫生出版社, 2015: 182.
[6]	British Society for Antimicrobial Chemotherapy(BSAC). BSAC Methods for Antimiceobial Susceptibility Testing[S]. 2009: 47-48.
[7]	Król-Turmińska K, Olender A, Bogut A. Tetracycline resistance in Moraxella catarrhalis clinical strains isolated in Poland[J]. New Microbiologica, 2020, 43(3):103-106.
[8]	Bernhard S, Spaniol V, Aebi C. Molecular pathogenesis of infections caused by Moraxella catarrhalis in children[J]. Swiss Med Wkly, 2012, 142:w13694.
[9]	Liu YL, Li DF, Xu HP, et al. Use of next generation sequence to investigate potential novel macrolide resistance mechanisms in a population of Moraxella catarrhalis isolates[J]. Sci Rep, 2016, 6:35711.
[10]	Farajzadeh Sheikh A, Ahmadi K, Nikakhlagh S. Detection of Streptococ-cus pneumoniae and Moraxella catarrhalis in patients with paranasal chronic sinusitis by polymerase chain reaction method[J]. J Chin Med Assoc, 2016, 79(8):440-444.
[11]	Santee CA, Nagalingam NA, Faruqi AA, et al. Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis[J]. Microbiome, 2016, 4(1):34.
[12]	Sy MG, Robinson JL. Community-acquired Moraxella catarrhalis pneumonia in previously healthy children[J]. Pediatr Pulmonol, 2010, 45(7):674-678.
[13]	Narang R, Bakewell K, Peach J, et al. Bac-terial distribution in the lungs of children with protracted bacterial bronchitis[J]. PLoS One, 2014, 9(9):e108523.
[14]	Shahani L, Tavakoli Tabasi S. Moraxella catarrhalis bacteraemia and prosthetic valve endocarditis[J]. BMJ Case Rep, 2015: bcr2014207368.
[15]	Sadjadi SA, Obedoza P, Annamarju P. Moraxella catarrhalis peritonitis[J]. Am J Case Rep, 2012, 13:19-21.
[16]	Jin Y. Moraxella catarrhalis meningitis: a case report[J]. Chin Med J, 2000, 113(4):381-382.
[17]	Rotta AT, Asmar BI, Ballal N, et al. Moraxella catarrhalis ventriculitis in a child with hydrocephalus and an external ventricular drain[J]. Pediatr Infect Dis J, 1995, 14(5):397-398.
[18]	Verjano SF, Calvo RC, Pérez NV. Moraxella catarrhalis as a cause of osteomyelitis in the infant[J]. An Esp Pediatr, 2002, 50(2):190-191.
[19]	Olivieri I, Padula A, Armignacco L, et al. Sep-tic arthritis caused by Moraxella catarrhalis associated with infliximab treatment in a patient with undifferentiated spondarthritis[J]. Ann Rheum Dis, 2004, 63(1):105-106.
[20]	孙淑红, 张伟, 胡晓峰, 等. 山东临沂地区下呼吸道感染患者卡他布兰汉菌耐药性分析及 bro 基因分型检测[J]. 中华临床感染病杂志, 2015, 8(3):253-257.
[21]	Du Y, Zhou H, Wang F, et al. Multilocus se-quence typing-based analysis of Moraxella catarrhalis population struc-ture reveals clonal spreading of drug-resistant strains isolated from childhood pneumonia[J]. Infect Genet Evol, 2017, 56:117-124.
[22]	Yamada K, Arai K, Saito R. Antimicrobial susceptibility to β-lactam antibiotics and production of BRO β-lactamase in clinical isolates of Moraxella catarrhalis from a Japanese hospital[J]. Microbiol Immunol Infect, 2017, 50(3):386-389.
[23]	Zhang Y, Zhang F, Wang H, et al. Antimicrobial susce-ptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respirato-ry tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program[J]. J Glob Antimicrob Resist, 2016, 5:36-41.
[24]	Todberg T, Koch A, Andersson M, et al. In-cidence of otitis media in a contemporary Danish National Birth Cohort[J]. PLoS One, 2014, 9(12):e111732.
[25]	Anezaki H, Terada N, Kawamura T, et al. Moraxella catarrhalis bacteremic pneumonia[J]. IDCase, 2020, 19:e00712.
[26]	Schaar V, Nordström T, Mörgelin M, et al. Moraxella catarrhalis outer membrane vesicles carry β-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin. Antimicrobial[J]. Agents Chemother, 55(8):3845-3853.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References