Journal of Clinical Pediatrics >
Cord blood transplantation in leukocyte adhesion deficiency type-1: a case report with 4 years follow-up
Received date: 2021-04-14
Online published: 2022-07-08
Leukocyte adhesion deficiency type-1 (LAD-1) is a primary immunodeficiency disease. It is caused by mutations in the ITGB2 gene that cause damage to leukocyte adhesion. It is characterized by recurrent infections, delayed detachment of the umbilical cord, impaired wound healing and leukocytosis. It can be cured by allogeneic hematopoietic stem cell transplantation. The patient was a boy. He started to have recurrent fever, pneumonia and enteritis at 1 month old. He was diagnosed as LAD-1 based on markedly elevated leukocyte counts and ITGB2 gene homozygous mutation. He was cured after undergoing cord blood transplantation at 6.5 months old. Umbilical cord blood stem cell transplantation is a safe and effective method to cure LAD-1.
Jiao CHEN , Zhouyang LIU , Shifen FAN , Fan JIANG , Zhixin JIANG , Yuan SUN . Cord blood transplantation in leukocyte adhesion deficiency type-1: a case report with 4 years follow-up[J]. Journal of Clinical Pediatrics, 2022 , 40(7) : 545 -549 . DOI: 10.12372/jcp.2022.21e0551
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