Commentary

Diagnosis and treatment strategy of childhood-onset systemic lupus erythematosus

  • Wei ZHOU
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  • National Children's Medical Center, Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Received date: 2022-06-15

  Online published: 2022-10-12

Abstract

Childhood-onset systemic lupus erythematosus (cSLE) is an autoimmune disease characterized by multiple organ involvement, a large number of autoantibodies and low complement. The affected organs are prone to irreversible damage, which threatens the lives of children. This article introduces the clinical characteristics of cSLE, severe lupus and monogenic lupus, and summarizes the diagnosis methods, disease activity assessment, treat-to-target, treatment principles and treatment schemes for different organ involvement of cSLE, and puts forward the treatment strategy of combination of traditional treatment and biological drugs, so as to better target the pathogenesis of cSLE, fully treat and control disease activity as soon as possible, reduce disease recurrence and side effects of traditional drugs, and provide reference for the continuous improvement of diagnosis and treatment of cSLE.

Cite this article

Wei ZHOU . Diagnosis and treatment strategy of childhood-onset systemic lupus erythematosus[J]. Journal of Clinical Pediatrics, 2022 , 40(10) : 721 -725 . DOI: 10.12372/jcp.2022.22e0849

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