With the development of prenatal imaging, molecular genetic diagnosis and intrauterine therapy, fetal medicine has faced new opportunities and challenges. To provide accurate prenatal diagnosis, genetic counseling and prognosis assessment for high-risk fetuses, and to develop a whole-process management plan of antenatal, perinatal and postnatal integration around sick fetuses and pregnant women on the premise of ensuring the safety of pregnant women, can improve the quality of life of children after birth. This paper analyzed two multidisciplinary diagnosis and treatment modes involving pediatric experts, fetal structure and developmental abnormalities, points out the existing problems and puts forward some suggestions to promote the high-quality development of fetal special disease diagnosis and treatment in China.