Objective To investigate the effect of respiratory rehabilitation on inspiratory muscle strength, exercise capacity, pulmonary function, asthma control level and quality of life in children with asthma. Methods The children with asthma treated in respiratory outpatient department from June 2021 to February 2022 were selected and randomly divided into experimental group and control group using a random number table. The control group was given routine drug treatment and health education, while the experimental group was combined with respiratory rehabilitation to observe its effects on children with asthma.Results A total of 57 children with asthma were included, all completed the 6-month experiment. There were 38 boys and 19 girls, with the average age of (9.4±2.3) years and the average disease course of 4.0 (2.1-5.5) years. There were 31 children in the experimental group and 26 children in the control group. After 6 months of training, the mean and maximum values of maximum oral inspiratory pressure, 6-minute walking distance, and asthma control level in the experimental group were higher than those in the control group (P<0.05), and the heart rate and quality of life scores after 6-minute walking were lower than those in the control group (P<0.05), but there was no significant difference in blood pressure and pulmonary function between the two groups (P>0.05). After 6 months of training, the mean and maximum values of maximum oral inspiratory pressure, 6-minute walking distance, lung function (FVC, FEV₁, PEF, MEF₇₅, MEF₅₀, MMEF_75/25), asthma control level in the experimental group were higher than those before the intervention (P<0.05), heart rate, systolic blood pressure and quality of life scores in the experimental group were lower than before the intervention (P<0.05), the mean value of maximum oral inspiratory pressure and pulmonary function (FEV₁, FEV₁/FVC, MEF₇₅, MEF₅₀, MEF₂₅, MMEF_75/25) in the control group were higher than those before the intervention (P<0.05). Conclusions Combining respiratory rehabilitation with standardized treatment can improve inspiratory muscle strength, exercise capacity, asthma control level and quality of life in children with asthma, and has good safety. Clinicians can apply respiratory rehabilitation to asthma patients in order to obtain better curative effect.