Journal of Clinical Pediatrics >
Relationship between blood lipids and age, coronary artery disease and its severity in the acute stage of Kawasaki disease
Received date: 2020-12-25
Online published: 2023-06-12
Objective To investigate the relationship between the changes of blood lipid and age, coronary artery disease and its severity in children with Kawasaki disease (KD). Methods A total of 241 children with acute KD admitted from January 2018 to December 2020 were selected as the study subjects (KD group), and 30 healthy children who underwent physical examination in our hospital were selected as the control group. The levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) were compared between the two groups. The differences in blood lipid levels among KD children of different ages, with or without coronary artery lesions (CAL) and with different severity of CAL were compared. Results There were 241 patients (135 boys and 106 girls) in KD group, and the median age was 2.17 (1.04-4.00) years. Forty children were <1 year old, 120 were 1-3 years old, and 81 were >3 years old. There were 94 children in the CAL group and 147 in the non-CAL group. In the CAL group, 68 children were grade Ⅱ, 17 were grade Ⅲ and 9 were grade Ⅳ. The control group included 30 patients (14 boys and 16 girls) and the median age was 3.00 (2.00-5.00) years. The TG and LDL-C levels of KD children in the acute stage were significantly higher than those in the control group, while the levels of TC and HDL-C were significantly lower than those in the control group, and there were statistically significant differences (P<0.05). There were statistically significant differences in TG among different age groups (P<0.05), and TG showed a decreasing trend with the increase of age. TG in the CAL group was significantly higher than that in the non-CAL group, and the difference was statistically significant (P<0.05). There were statistically significant differences in TG among CAL groups with different severity (P<0.05). Conclusions In the acute stage of KD, the levels of TC and HDL-C were decreased, while the levels of TG and LDL-C were increased. The TG level was correlated with the age, whether CAL was complicated or not, and the severity of CAL in KD children.
Key words: Kawasaki disease; blood lipids; coronary artery lesion; child
Fangyuan HE , Xuehua HE , Yonghua YUAN , Liurong ZHU , Yi WU , Xiaohui XIA . Relationship between blood lipids and age, coronary artery disease and its severity in the acute stage of Kawasaki disease[J]. Journal of Clinical Pediatrics, 2023 , 41(6) : 455 -458 . DOI: 10.12372/jcp.2023.22e1030
[1] | Kobayashi T, Ayusawa M, Suzuki H, et al. Revision of diagnostic guidelines for Kawasaki disease (6th revised edition)[J]. Pediatr Int, 2020, 62(10): 1135-1138. |
[2] | 中华医学会儿科学分会心血管学组, 中华儿科杂志编辑委员会. 川崎病冠状动脉病变的临床处理建议(2020年修订版)[J]. 中华儿科杂志, 2020, 58(9): 718-724. |
[3] | 何学华, 朱潜力, 袁勇华, 等. 川崎病合并冠状动脉瘤患儿应用华法林治疗的安全性[J]. 中华儿科杂志, 2021, 59(2): 95-100. |
[4] | Newburger JW, Burns JC, Beiser AS, et al. Altered lipid profile after Kawasaki syndrome[J]. Circulation, 1991, 84(2): 625-631. |
[5] | Yoshioka T, Matsutani T, Iwagami S, et al. Polyclonal expansion of TCRBV2- and TCRBV6-bearing T cells in patients with Kawasaki disease[J]. Immunology, 1999, 96(3): 465-472. |
[6] | Hourigan ST, Solly EL, Nankivell VA, et al. The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis[J]. Sci Rep, 2018, 8(1): 13596. |
[7] | Yeom JS, Woo HO, Park JS, et al. Kawasaki disease in infants[J]. Korean J Pediatr, 2013, 56(9): 377-382. |
[8] | Fernandez-Cooke E, Barrios Tascón A, Sánchez-Manubens J, et al. Epidemiological and clinical features of Kawasaki disease in Spain over 5 years and risk factors for aneurysm development. (2011-2016): KAWA-RACE study group[J]. PLoS One, 2019, 14(5): e0215665. |
[9] | 王复娟, 吴良霞. 川崎病冠状动脉损害相关危险因素分析[J]. 临床儿科杂志, 2020, 38(7): 481-484. |
[10] | Peng Y, Liu X, Duan Z, et al. Age-related differences in clinical characteristics of Kawasaki disease[J]. Braz J Med Biol Res, 2021, 54(3): e10281. |
[11] | Shao S, Zhou K, Liu X, et al. Predictive value of serum lipid for intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease[J]. J Clin Endocrinol Metab, 2021, 106(10): e4210-e4220. |
[12] | 廖先华, 许玉霞, 刘增荣. 川崎病患儿血脂代谢与冠状动脉病变的关系[J]. 华西医学, 2010, 25(6): 1036-1038. |
/
〈 |
|
〉 |