Non-typhoid Salmonella belongs to Salmonella enterica, which mainly causes acute gastroenteritis after infecting human beings, and children under 5 years old are susceptible to it. It is more common in summer. Diarrhea and fever are the most common symptoms, fecal traits are diverse, and the most common serotypes are Salmonella enteritidis, Salmonella typhimurium and Salmonella Newport. Most patients only need symptomatic treatment such as fluid replacement and electrolyte disturbance correction. Antibacterial drugs should be considered for people with invasive infection risk and Salmonella typhimurium infection, the third-generation cephalosporin is the first choice for children. In recent years, the drug resistance rate of NTS in China has an increasing trend, and patients with suspected infection should try their best to improve the etiological detection before starting anti-infective treatment. There are still many controversies in the clinical diagnosis and treatment of non-typhoid Salmonella infection. Improving the etiological diagnosis rate of clinical cases, promoting rapid pathogen diagnosis methods, and carrying out high-quality evidence-based clinical trials will help to standardize the diagnosis and treatment of non-typhoid Salmonella gastroenteritis.