Journal of Clinical Pediatrics >

2023 , Vol. 41 >Issue 11: 820 - 826

DOI: https://doi.org/10.12372/jcp.2023.22e1371

Digestive System Disease

Efficacy and safety of endoscopic resection of giant polyps in pediatric patients with Peutz-Jeghers syndrome

  • Fengge WANG ,
  • Buyun SHI ,
  • Zhihua HUANG ,
  • Zhenni ZHU ,
  • Daiqin WU
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  • 1. Department of Paediatric Gastroenterology, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei 430070, China
    2. Department of Pediatric Intensive Care, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei 430070, China
    3. Department of Pediatrics, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

Received date: 2022-10-17

  Online published: 2023-11-08

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Abstract

Objective To investigate the clinical characteristics of children with Peutz-Jeghers syndrome (PJS) and the efficacy and safety of endoscopic resection of giant polyposis in children with PJS. Methods The clinical data of 11 children with PJS who were hospitalized in hospital from January 2019 to August 2022 were collected. The number, distribution of polyps detected and resected endoscopically, and operation related complications were retrospectively analyzed. Results The mean age of first visit was (8.7±3.0) years. All patients have hyperpigmentation on their lips, fingers and toes. Sixteen DBE procedures were performed, and total gastrointestinal examinations were conducted in two cases. 18 polyps >3cm were found, including 12 in the small intestine, 1 in the stomach and 5 in the colon, all of which were resected under endoscopy. Sore throat happened in all cases who underwent DBE via the oral route, abdominal distension in 2 cases, vomiting in 1 case, delayed bleeding in 1 case, but no serious complications in all cases. Conclusion Gastrointestinal endoscopy, especially DBE, can effectively remove gastrointestinal polyps, is safe and effective for the treatment of pediatric patients with PJS.

Key words： Peutz-Jeghers syndrome; giant polyps; double-balloon enteroscopy; pediatric patients

Cite this article

Fengge WANG , Buyun SHI , Zhihua HUANG , Zhenni ZHU , Daiqin WU . Efficacy and safety of endoscopic resection of giant polyps in pediatric patients with Peutz-Jeghers syndrome[J]. Journal of Clinical Pediatrics, 2023 , 41(11) : 820 -826 . DOI: 10.12372/jcp.2023.22e1371

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