Objective To investigate the serotypes and antibiotics-resistance of Salmonella enteric causing enteritis in children, to provide reference for clinical experience treatment. Methods A retrospective study was conducted and the laboratory data of patients with Salmonella infection between January 2019 and June 2022 were collected, VITEK 2 GNS card and disk diffusion method were used for drug susceptibility test of Salmonella, and diagnostic serum slide agglutination method was used for serotyping. Results A total of 1014 Salmonella isolates were cultured, 55.7% (565/1014) from males and the medium (quartile) age of all patients were 14 (9, 26) months. The positive rate for Salmonella culture in outpatients (15.2%) was significant higher than that in inpatients (2.3%, P<0.001). The peak of positive rate for Salmonella was 9.53% which occurred in July. Subspecies enterica accounted for 99.9%, of which group B, group C, group D, group E and other Salmonella enterica accounted for 67.3%, 13.0%, 11.9%, 5.2% and 2.5%, respectively. The most common was Salmonella typhimurium (48.7%) and it’s proportion increasing yearly. The results of antibiotics susceptibility test showed that the resistant-rates of the strains to ampicillin, ampicillin-sulbactam, ceftriaxone, trimethoprim-sulfamethoxazole, ciprofloxacin and imipenem were 75.5%, 70.7%, 25.3%, 39.0%, 10.9% and 1.4%, respectively, and higher resistant-rates of these antibiotics in Salmonella typhimurium isolates were identified when compared with that ofother strains (P<0.05). Conclusion The resistance rate of Salmonella enteric to ampicillin was high. The resistance rates of Salmonella enterica to commonly used antibiotics varied in strains with different serogroups or serotypes, which should be considered when prescribed antibiotics empirically in treating Salmonella infection.