Expert Review

Renal pathologic classification and treatment strategy in children with lupus nephritis

  • Chunlin GAO
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  • Department of Pediatrics, Jinling Hospital; Department of Pediatrics, Jinling Hospital, Medical School of Nanjing University; Department of Pediatrics, Jinling Hospital, Nanjing Medical University; Department of Pediatrics, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing 210002, Jiangsu, China

Received date: 2023-09-18

  Online published: 2023-12-04

Abstract

Lupus nephritis (LN) is the most common glomerular disease in children, with a more severe onset and progression compared to adults. The prognosis of LN in children is worse than other glomerular diseases and has lifelong effects, although the etiology remains unclear. This article provides an overview of the current diagnosis and treatment status of LN in children, along with a brief description of the treatment for each type of LN based on the latest international guidelines. LN was diagnosed according to the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus. Renal biopsy pathology is an important diagnostic method at present. Treatment for proliferative and non-proliferative LN includes initial therapy and maintenance therapy, following recommendations from adult guidelines. Rational and proactive treatment is crucial for inducing disease remission, preventing relapse, and improving prognosis.

Cite this article

Chunlin GAO . Renal pathologic classification and treatment strategy in children with lupus nephritis[J]. Journal of Clinical Pediatrics, 2023 , 41(12) : 887 -894 . DOI: 10.12372/jcp.2023.23e0916

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