Journal of Clinical Pediatrics >
Research progress of gut microbiota in allergic diseases in children
Received date: 2023-11-01
Online published: 2024-08-06
In recent years, allergic diseases continue to pose a major threat and challenge to the health of a wide range of children, thereby calling for urgent intervention to prevent the progression of the disease. The human gut microbiota is established by the age of 3 years. The imbalance in the gut microbiota occurs due to factors, such as cesarean delivery and antibiotic use before the age of 3 years, is strongly associated with a higher risk of future onset of allergic diseases. Recent advancements in next-generation sequencing methods have revealed the presence of dysbiosis in patients with allergic diseases, which increases attention on the relationship between dysbiosis and the development of allergic diseases. A large number of researchers have conducted in-depth research on the correlation between gut microbiota and allergic diseases, and the research results have revealed that the imbalance of gut microbiota is associated with the high risk of children developing allergic diseases in the future, and the changes in gut microbiota may be used as therapeutic targets for allergic diseases. Therefore, the purpose of this paper is mainly to review the latest research progress of gut microbiota in children with allergic diseases, and try to further promote the treatment and prevention of clinical diseases by comparing the gut microbiota of children with allergic diseases and normal children.
Key words： gut microbiota; allergic diseases; asthma; food allergy; child
Menglu Reviewer:DENG , Jie Reviser:ZHANG , Wenbin SHENG . Research progress of gut microbiota in allergic diseases in children[J]. Journal of Clinical Pediatrics, 2024 , 42(8) : 741 -746 . DOI: 10.12372/jcp.2024.23e1054
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