Commentary

The Shanghai Maternal-Child Pairs Cohort (MCPC) and its application in clinical research

  • Yunhui ZHANG ,
  • Huijing SHI ,
  • Xiaowen ZHAI
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  • 1. School of Public Health, Fudan University, Key Laboratory of Public Health, Ministry of Education, Shanghai 200032, China
    2. Children’s Hospital of Fudan University, Shanghai 201102, China

Received date: 2024-08-12

  Online published: 2024-09-04

Abstract

The rapid development of socio-economics has led to prominent derivative issues such as changes in psychological health, behavioral lifestyles, and environmental quality, which urgently require long-term cohort studies on birth cohorts. These studies should focus on the impact of material and social environmental factors on the health of people in mega-cities and seek the patterns and risk factors of diseases in the new era. The Shanghai Maternal-Child Pairs Cohort (MCPC) adopts a comprehensive and meticulous follow-up approach that integrates "community + obstetric hospitals + schools," conducting 13 follow-ups on 6714 mother-child pairs from early to mid-pregnancy, the delivery period, and the offspring from birth to six years old. MCPC has established a follow-up information database containing millions of data entries, including standardized questionnaires, maternal and child disease diagnosis, child physical growth, body composition, spinal deformities, fingerprint and palmprint, grip strength, physical activity, cognitive ability, and language development level tests, as well as clinical medical records. Additionally, a biobank has been created with 600000 samples from 17 categories, including peripheral blood, umbilical cord blood, finger prick blood, meconium, placenta, urine, feces, buccal mucosa, hair, and nails. Furthermore, 21 standardized SOP documents have been formulated to manage and control the entire process of the sample bank, from collection to cold chain transportation, storage, retrieval, and return. This cohort platform not only provides crucial support for revealing the impact of early-life environmental exposures on population health and multi-omics research but also promotes interdisciplinary innovation.

Cite this article

Yunhui ZHANG , Huijing SHI , Xiaowen ZHAI . The Shanghai Maternal-Child Pairs Cohort (MCPC) and its application in clinical research[J]. Journal of Clinical Pediatrics, 2024 , 42(9) : 758 -767 . DOI: 10.12372/jcp.2024.24e0817

References

[1] Eriksson JG. Epidemiology, genes and the environment: lessons learned from the Helsinki Birth Cohort Study[J]. J Intern Med, 2007, 261(5): 418-425.
[2] Olsen J. The Danish National Birth Cohort - a data source for studying preterm birth[J]. Acta Obstet Gynecol Scand, 2005, 84(6): 539-540.
[3] Tao FB, Hao JH, Huang K, et al. Cohort profile: the China-Anhui Birth Cohort Study[J]. Int J Epidemiol, 2013, 42(3): 709-721.
[4] Qiu X, Lu JH, He JR, et al. The Born in Guangzhou Cohort Study (BIGCS)[J]. Eur J Epidemiol, 2017, 32(4): 337-346.
[5] Zheng JS, Liu H, Jiang J, et al. Cohort Profile: The Jiaxing Birth Cohort in China[J]. Int J Epidemiol, 2017, 46(5): 1382-1382g.
[6] Zhang J, Tian Y, Wang W, et al. Cohort profile: the Shanghai Birth Cohort[J]. Int J Epidemiol, 2019, 48(1): 21-21g.
[7] Zhang X, Gong Y, Chen Y, et al. Nutrition in Pregnancy and Growth in Southwest China (NPGSC) cohort: Design, implementation, and characteristics[J]. Paediatr Perinat Epidemiol, 2020, 34(6): 724-733.
[8] 杜江波, 丁叶, 黄磊, 等. 中国国家出生队列孤独症谱系障碍亚队列建设概况[J]. 中华流行病学杂志, 2021, 42(4): 591-596.
[9] 胡志斌, 杜江波, 徐欣, 等. 中国国家出生队列建设背景和设计简介[J]. 中华流行病学杂志, 2021, 42(4): 569-574.
[10] Yue W, Zhang E, Liu R, et al. The China birth cohort study (CBCS)[J]. Eur J Epidemiol, 2022, 37(3): 295-304.
[11] Gui Y, Zhao Y, Tao XG, et al. Cohort profile: The Shanghai Maternal-Child Pairs Cohort (MCPC)[J]. Int J Epidemiol, 2024, 53(1): dyad185.
[12] Tan L, Zou J, Zhang Y, et al. A longitudinal study of physical activity to improve sleep quality during pregnancy[J]. Nat Sci Sleep, 2020, 12: 431-442.
[13] Ma X, Wei Q, Jiang Z, et al. The role of serum oxytocin levels in the second trimester in regulating prenatal anxiety and depression: A sample from Shanghai Maternal-Child Pairs Cohort study[J]. J Affect Disord, 2020, 264: 150-156.
[14] Ma X, Wang Y, Hu H, et al. The impact of resilience on prenatal anxiety and depression among pregnant women in Shanghai[J]. J Affect Disord, 2019, 250: 57-64.
[15] Wei Q, Zou J, Ma X, et al. Prospective associations between various prenatal exposures to maternal psychological stress and neurodevelopment in children within 24 months after birth[J]. J Affect Disord, 2023, 327: 101-110.
[16] Shi YY, Wei Q, Ma X, et al. Maternal affective and stress-related factors during pregnancy affect the occurrence of childhood allergic diseases: A Shanghai MCPC study[J]. J Psychosom Res, 2023, 165:111142.
[17] Wang K, Qi Y, Wei Q, et al. Responsive caregiving and opportunities for early learning associated with infant development: Results from a prospective birth cohort in China[J]. Front Pediatr, 2022, 10: 857107.
[18] Yang Y, Zou J, Wei Q, et al. A longitudinal study of the effects of bed-sharing experience in infancy on sleep outcomes at 2 years old[J]. J Pediatr, 2022, 245: 142-148.
[19] Zou JJ, Wei Q, Shi YY, et al. Longitudinal associations between maternal glucose levels and ultrasonographic fetal biometrics in a Shanghai cohort[J]. JAMA Netw Open, 2022, 5(4): e226407.
[20] Zou J, Wei Q, Ye P, et al. Effects of gestational sleep patterns and their changes on maternal glycemia and offspring physical growth in early life[J]. Nutrients, 2022, 14(16): 3390.
[21] Jing G, Wei Q, Zou J, et al. Longitudinal association between maternal cardiovascular health in pregnancy and child birth outcomes[J]. Sci Rep, 2024, 14(1): 15355.
[22] Jing G, Ye P, Wei Q, et al. Prospective associations of maternal cardiometabolic health with children cardiometabolic health at ages 3 to 6 years[J]. J Clin Endocrinol Metab, 2024: dgae413.
[23] Li J, Li Q, Li J, et al. Simultaneous determination of poly- and perfluoroalkyl substances and organophosphorus flame retardants in serum by ultra-performance liquid chromatography/tandem mass spectrometry[J]. Rapid Commun Mass Spectrom, 2022, 36(14): e9312.
[24] Zhao Y, Zhou Y, Zhu Q, et al. Determination of antibiotic concentration in meconium and its association with fetal growth and development[J]. Environ Int, 2019, 123: 70-78.
[25] Zhou Y, Zhang L, Li Q, et al. Prenatal PFAS exposure, gut microbiota dysbiosis, and neurobehavioral development in childhood[J]. J Hazard Mater, 2024, 469: 133920.
[26] Zhou Y, Li Q, Wang P, et al. Associations of prenatal PFAS exposure and early childhood neurodevelopment: Evidence from the Shanghai Maternal-Child Pairs Cohort[J]. Environ Int, 2023, 173: 107850.
[27] Wang H, Wang P, Li Q, et al. Prenatal exposure of organophosphate esters and its trimester-specific and gender-specific effects on fetal growth[J]. Environ Sci Technol, 2022, 56(23): 17018-17028.
[28] Xu Y, Sui X, Li J, et al. Early-life exposure to per- and polyfluoroalkyl substances: Analysis of levels, health risk and binding abilities to transport proteins[J]. Eco-Environment & Health, 2024, 3(3): 308-316.
[29] Zhou Y, Zhu Q, Wang P, et al. Early pregnancy PM2.5exposure and its inorganic constituents affect fetal growth by interrupting maternal thyroid function[J]. Environ Pollut, 2022, 307: 119481.
[30] Zhao Y, Wang P, Zhou Y, et al. Prenatal fine particulate matter exposure, placental DNA methylation changes, and fetal growth[J]. Environ Int, 2021, 147: 106313.
[31] Li J, Ma W, Zhao Y, et al. Lactational exposure of polybrominated diphenyl ethers and its association with infant developmental measurements[J]. J Hazard Mater, 2020, 388: 122031.
[32] Huang Y, Wang P, Law JC, et al. Organic UV filter exposure and pubertal development: A prospective follow-up study of urban Chinese adolescents[J]. Environ Int, 2020, 143: 105961.
[33] Zhang Y, Cao Y, Shi H, et al. Could exposure to phthalates speed up or delay pubertal onset and development? A 1.5-year follow-up of a school-based population[J]. Environ Int, 2015, 83: 41-49.
[34] Shi H, Cao Y, Shen Q, et al. Association between urinary phthalates and pubertal timing in Chinese adolescents[J]. J Epidemiol, 2015, 25(9): 574-582.
[35] Zhao Y, Song Q, Ge W, et al. Associations between in utero exposure to polybrominated diphenyl ethers, pathophysiological state of fetal growth and placental DNA methylation changes[J]. Environ Int, 2019, 133(Pt B): 105255.
[36] Zhao Y, Gong X, Chen L, et al. Site-specific methylation of placental HSD11B2 gene promoter is related to intrauterine growth restriction[J]. Eur J Hum Genet, 2014, 22(6): 734-740.
[37] Wang P, Zhou Y, Zhao Y, et al. Prenatal fine particulate matter exposure associated with placental small extracellular vesicle derived microRNA and child neurodevelopmental delays[J]. Sci Total Environ, 2022, 841: 156747.
[38] Xia B, Zhu Q, Zhao Y, et al. Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence[J]. Environ Int, 2018, 121(Pt 1): 159-168.
[39] Upadhyay R, Taneja S, Chowdhury R, et al. Child neurodevelopment after multidomain intervention from preconception through early childhood: The WINGS randomized clinical trial[J]. JAMA, 2024, 331(1): 28-37.
[40] Gao Y, Zheng K, Kang M, et al. Establishment and characterization of a novel cell line (SCCOHT-CH-1) and PDX models derived from Chinese patients of small cell ovarian carcinoma of the hypercalcemic type[J]. Hum Cell, 2023, 36(6): 2214-2227.
[41] Zheng K, Gao Y, Xu C, et al. Clinical characteristics and status of treatment of small-cell carcinoma of the ovary, hypercalcemic type in the Chinese population: a meta-analysis[J]. J Gynecol Oncol, 2024, 35(4): e96.
[42] Gao Y, Zang L, Ye Y, et al. Immunotherapy combined with targeted therapy in advanced small cell carcinoma of the ovary of hypercalcemic type: A case of overall survival lasting for over 5 years[J]. Eur J Obstet Gynecol Reprod Biol, 2024, 297: 270-274.
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