Journal of Clinical Pediatrics >
Clinical manifestations and progress in diagnosis and treatment of digestive system involvement in children with juvenile systemic lupus erythematosus
Received date: 2023-10-10
Online published: 2024-10-08
Digestive system involvement is common in juvenile systemic lupus erythematosus (JSLE). Gastrointestinal involvement occurs in 15% to 60% of children with JSLE, and 2% to 30% of gastrointestinal symptoms are directly attributable to JSLE. The main pathological changes of JSLE are inflammation and vasculitis, and the symptoms are not specific. Clinically, it can be manifested as lupus mesenteric vasculitis, hepatitis and pancreatitis, so early recognition is of great significance. For children with JSLE who present with digestive system symptoms, the cause should be identified based on objective laboratory findings and treated accordingly. Once it is clear that the digestive system is caused by JSLE itself, adequate glucocorticoids should be used intravenously at an early stage, and pulse therapy should be given if necessary. This paper reviews the progress of etiology, pathology, clinical manifestations, diagnosis, differential diagnosis and treatment of JSLE digestive system involvement, and provides suggestions for further improving the diagnosis and treatment norms applicable to JSLE digestive system involvement.
Key words： systemic lupus erythematosus; digestive tract; diagnosis; treatment; juvenile
Tong Reviewer: JIN , Chang LIU , Xue Reviser: ZHAO . Clinical manifestations and progress in diagnosis and treatment of digestive system involvement in children with juvenile systemic lupus erythematosus[J]. Journal of Clinical Pediatrics, 2024 , 42(10) : 895 -901 . DOI: 10.12372/jcp.2024.23e0969
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