Journal of Clinical Pediatrics >
Characteristic analysis of acute brucellosis in children with abnormal transaminase
Received date: 2023-07-16
Online published: 2024-11-08
Objective The purpose of this study was to investigate the clinical characteristics of acute brucellosis with abnormal transaminase in children. Methods The data of 43 patients diagnosed with brucellosis from January 2015 to December 2021 were analyzed retrospectively. Based on transaminase values, the patients were divided into 2 groups: abnormal transaminase group and normal transaminase group. The clinical manifestations and laboratory indexes of two groups were analyzed. Result Abnormal transaminase was found in 74.41% of study group and mainly consist of mild and moderate abnormalities. The proportion of splenomegaly in abnormal transaminase group was higher than that in normal transaminase group (P<0.05). In the patients who had abnormal transaminase, the hemoglobin and platelet values were lower, and the blood culture positive rate were higher (P<0.05). The proportion of CD3+CD4-CD8-T cells was significantly higher than that of normal transaminase group (P<0.05) and the percentage of CD3+CD4-CD8-T cells was positively correlated with ALT and AST values (r=0.601, 0.466). The recovery time of transaminase was 1-3 weeks for mild abnormal transaminase, and 3-6 weeks for moderate and severe abnormal transaminase. Conclusion The proportion of children with acute brucellosis complicated with abnormal transaminase is higher, with mild and moderate abnormalities being predominant. Acute brucellosis complicated with abnormal transaminase in children has a favorable prognosis. Percentage of CD3+CD4-CD8-T cells may be related to abnormal transaminase in children with acute brucellosis.
Key words： acute brucellosis; abnormal transaminase; double negative T cells; child
Yanhong JIA , Fang GUO , Xiaoyuan WU , Li JIA , Xin ZHAO , Wenhui LI . Characteristic analysis of acute brucellosis in children with abnormal transaminase[J]. Journal of Clinical Pediatrics, 2024 , 42(11) : 907 -911 . DOI: 10.12372/jcp.2024.23e0662
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