Journal of Clinical Pediatrics >
The value of measuring trace elements and oxidative/antioxidant factors in umbilical blood in predicting the onset and evaluation of neonatal respiratory distress syndrome
Received date: 2024-04-28
Accepted date: 2024-08-30
Online published: 2025-02-27
Objective To determine the trace elements and oxidative/antioxidant factors in cord blood of premature infants, and to clarify their value in predicting the onset and evaluation of neonatal respiratory distress syndrome (NRDS). Methods Premature infants with gestational age less than 34 weeks who were hospitalized in the neonatal department from Dec. 2022 to Dec. 2023 were selected as the subjects. The levels of trace elements were determined by flame atomic absorption spectroscopy, and the levels of oxidative factor malondialdehyde (MDA) and antioxidant factor superoxide dismutase (SOD) were measured by surface linked immunosorbent assay. The differences in the above indicators between the NRDS group and the control group were compared. The value of each indicator in predicting the onset of NRDS were determined by the receiver operative curve (ROC). Results The cord blood copper levels and zinc levels in the NRDS group were significantly lower than those in the control group. The SOD level in the NRDS group was lower than that in the control group, and the MDA level was higher than that in the control group. Meanwhile, the SOD/MDA ratio in the NRDS group was significantly lower than that in the control group. The area under the curve of zinc, copper, SOD, MDA, and SOD/MDA in cord blood predicting the onset of NRDS were 0.728, 0.917, 0.627, 0.780, and 0.824, respectively. Conclusions The decrease in levels of trace elements copper and zinc in cord blood and the imbalance of oxidative/antioxidant factors are involved in the pathogenesis of neonatal respiratory distress syndrome.
HUANG Jing , LIU Xiaochen , GAO Xiong , LI Xiaowen , LI Guanghong , LI Luquan . The value of measuring trace elements and oxidative/antioxidant factors in umbilical blood in predicting the onset and evaluation of neonatal respiratory distress syndrome[J]. Journal of Clinical Pediatrics, 2025 , 43(3) : 204 -210 . DOI: 10.12372/jcp.2025.24e0424
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