Journal of Clinical Pediatrics >
Application and consideration of eculizumab in the treatment of childhood systemic lupus erythematosus
Received date: 2025-03-05
Accepted date: 2025-04-21
Online published: 2025-06-01
Systemic lupus erythematosus (SLE) is one of the most common systemic autoimmune diseases in children. Thrombotic microangiopathy (TMA) is one of the serious complications of SLE. SLE patients with concurrent TMA often have a poor prognosis and a higher mortality rate. Eculizumab is a humanized monoclonal anti-C5 antibody, which is the preferred treatment for atypical hemolytic uremic syndrome (aHUS) in both adults and children. Currently, Eculizumab is used for the clinical treatment of pediatric SLE combined with TMA, and has achieved positive outcomes. This article reviews and summarizes current published studies on the application of eculizumab in treating pediatric SLE. From the perspective of pediatric nephrologists, it elaborates on some personal insights regarding the selection of indications, treatment timing, treatment course, and adverse reactions of eculizumab in the treatment of pediatric SLE. Some issues in the treatment of pediatric SLE with eculizumab still need to be further addressed by future multi-center, large-sample, and multi-level treatment regimen randomized controlled studies.
ZHANG Hongwen . Application and consideration of eculizumab in the treatment of childhood systemic lupus erythematosus[J]. Journal of Clinical Pediatrics, 2025 , 43(6) : 403 -407 . DOI: 10.12372/jcp.2025.25e0192
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