Journal of Clinical Pediatrics >
Progress in pathogenesis and treatment of pediatric generalized pustular psoriasis
Received date: 2024-11-25
Accepted date: 2025-01-07
Online published: 2025-06-27
Generalized pustular psoriasis (GPP) is a rare, recurrent systemic inflammatory skin disease. Interleukin (IL)-36RN (IL36RN) is the most common causative gene in GPP. Innate immunity mediated by IL-1/IL-36-chemokine-neutrophils plays a central role in the pathogenesis of GPP, and adaptive immunity mediated by tumor necrosis factor-α (TNF-α)/IL-23/IL-17 is also involved in GPP pathogenesis. At present, the main therapeutic agents for GPP are acitretin, methotrexate, cyclosporine and biologics. Most of the biologics are still used as over-indications in pediatric GPP. There is increasing evidence that adalimumab and secukinumab have achieved better efficacy in the treatment of GPP in children. Spesolimab, an IL-36 receptor inhibitor, is a new therapeutic target for GPP, bringing new hope for the treatment and prevention of GPP. This article reviews the pathogenesis and treatment progress of GPP in children, and provides reference for the clinical diagnosis and treatment of the disease.
Key words： generalized pustular psoriasis; pathogenesis; treatment progress; biologics; child
LYU Mingjun , LUO Wen , YANG Jinxiang , LIANG Jianying , YAO Zhirong . Progress in pathogenesis and treatment of pediatric generalized pustular psoriasis[J]. Journal of Clinical Pediatrics, 2025 , 43(7) : 556 -562 . DOI: 10.12372/jcp.2025.24e1264
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