Journal of Clinical Pediatrics >

2025 , Vol. 43 >Issue 12: 915 - 921

DOI: https://doi.org/10.12372/jcp.2025.25e0814

Original Article

Preliminary exploration on establishment of normal reference value for auditory event related potentials in children

  • WEI Lin ,
  • SHEN Jiali ,
  • MA Xiaobao ,
  • WANG Wei ,
  • WANG Lu ,
  • JIN Yulian ,
  • YANG Jun ,
  • ZHENG Guiliang ,
  • LOU Gaozhong ,
  • ZHAO Zhehong ,
  • CHEN Jianyong
Expand
  • 1. Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Translational Medicine of Ear and Nose Disease, Shanghai 200092, China
    2. Department of Otolaryngology, Hangzhou Maternal and Child Health Care Hospital, Hangzhou Children's Hospital, Hangzhou 310006, Zhejiang, China
    3. Department of Otolaryngology, General Hospital of Medical Community, Shaoxing Central Hospital, Shaoxing 312030, Zhejiang, China

Received date: 2025-07-11

  Accepted date: 2025-09-22

  Online published: 2025-11-28

Fold

Abstract

Objective To establish a range of clinical reference values for each component of P1, N1, P2, N2, and P3 in auditory event related potentials (AERPs) in normal children aged 6-17 years, and to provide an assessment of cognitive impairments caused by clinically relevant diseases in children. Methods Healthy children with normal hearing who visited the Diagnosis and Treatment Center for Hearing Impairment and Vertigo between January 2024 and January 2025 were selected as study participants. AERPs were recorded using the auditory Oddball paradigm. Differences in AERP waveform components between both ears were compared, and normative values for the latency and amplitude of each AERP component were established. Results A total of 28 healthy children (56 ears) with normal hearing aged 6 to 17 years were included, with an average age of (8.75±2.40) years, including 15 boys (30 ears) and 13 girls (26 ears). The normal latency of each wave component of AERP in children is as follows: P1 (56.00±13.11) ms, N1 (106.36±15.26) ms, P2 (183.29±26.77) ms, N2 (229.21±26.28) ms and P3 (329.89±22.32) ms. The 95% confidence intervals (CI) are: P1 (30.29-81.71) ms, N1 (76.44-136.27) ms, P2 (130.82-235.75) ms, N2 (177.71-280.72) ms, and P3 (286.14-373.64) ms. The amplitude values are as follows: P1 [6.91 (4.91 - 10.92)] μV, P1-N1 [9.26 (4.82 - 14.79)] μV, N1-P2 [9.90 (5.60-14.25)] μV, P2-N2 [6.21 (4.40-9.94)] μV and N2-P3 [10.68 (5.95-15.81)] μV; 95% confidence intervals are: P1 (5.37-10.43) μV, P1-N1 (6.06-11.79) μV, N1-P2 (6.96-12.98) μV, P2-N2 (5.20-8.80) μV and N2-P3 (9.15-14.93) μV. Conclusions This study initially established the normal reference values of each component of AERPs for children aged 6 to 17, which is helpful in providing data support for the clinical assessment of cognitive function impairment in children.

Key words： auditory event-related potentials; normative reference value; cognitive function; child

Cite this article

WEI Lin , SHEN Jiali , MA Xiaobao , WANG Wei , WANG Lu , JIN Yulian , YANG Jun , ZHENG Guiliang , LOU Gaozhong , ZHAO Zhehong , CHEN Jianyong . Preliminary exploration on establishment of normal reference value for auditory event related potentials in children[J]. Journal of Clinical Pediatrics, 2025 , 43(12) : 915 -921 . DOI: 10.12372/jcp.2025.25e0814

References

[1] Patel SH, Azzam PN. Characterization of N200 and P300: selected studies of the event-related potential[J]. Int J Med Sci, 2005, 2(4): 147-154.
[2] Sowndhararajan K, Kim M, Deepa P, et al. Application of the P300 event-related potential in the diagnosis of epilepsy disorder: a review[J]. Sci Pharm, 2018, 86(2): 10.
[3] Sur S, Sinha VK. Event-related potential: an overview[J]. Ind Psychiatry J, 2009, 18(1): 70-73.
[4] Duncan CC, Barry RJ, Connolly JF, et al. Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400[J]. Clin Neurophysiol, 2009, 120(11): 1883-1908.
[5] Key AP, Dove GO, Maguire MJ. Linking brainwaves to the brain: an ERP primer[J]. Dev Neuropsychol, 2005, 27(2): 183-215.
[6] Kestens K, Van Yper L, Degeest S, et al. The P300 auditory evoked potential: a physiological measure of the engagement of cognitive systems contributing to listening effort?[J]. Ear Hear, 2023, 44(6): 1389-1403.
[7] Donkers FC, Carlson M, Schipul SE, et al. Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development[J]. Autism, 2020, 24(5): 1093-1110.
[8] 全国声学标准化技术委员会. GB/T 16296.1—2018 《声学测听方法第1部分: 纯音气导和骨导测听法》[S]. 2018. https://kns.cnki.net/kcms2/article/abstract?v=7qDgw1F_0HWFFOtBWhWPY2Rpu6aR1xov9euiA1QnbYEMS2MmJgkq6F9 RhcJI9vaBp8mIgFVWEHfDg7vErSa3mXNFEvT3Pf575drKHRf26TvXfzehwCtsEWVjN72pmwxVfLPK-Bp3FkxE9hnn6ECn1G06pO1a QCNT&uniplatform=NZKPT
[9] Shubhadarshan A, Gaiwale U. Effect of advancing age on event-related potentials (P300) measures[J]. Egypt J Otolaryngol, 2024, 40(1): 107.
[10] 陈建勇, 朱海月, 沈佳丽, 等. 听力正常青年人普通话可接受噪声级与皮层听觉诱发电位的相关性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2022, 36(9): 679-684.
  Chen JY, Zhu HY, Shen JL, et al. Correlation between Mandarin acceptable noise level and cortical auditory evoked potential in young normal-hearing listeners[J]. Linchuang Erbiyanhou Toujing Waike Zazhi, 2022, 36(9): 679-684.
[11] Tsai ML, Hung KL, Lu HH. Auditory event-related potentials in children with attention deficit hyperactivity disorder[J]. Pediatr Neonatol, 2012, 53(2): 118-124.
[12] Sharma A, Kraus N, McGee TJ, et al. Developmental changes in P1 and N1 central auditory responses elicited by consonant-vowel syllables[J]. Electroencephalogr Clin Neurophysiol, 1997, 104(6): 540-545.
[13] Picton TW. The P300 wave of the human event-related potential[J]. J Clin Neurophysiol, 1992, 9(4): 456-479.
[14] Tomé D, Barbosa F, Nowak K, et al. The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values[J]. J Neural Transm (Vienna), 2015, 122(3): 375-391.
[15] Folstein JR, Van Petten C. Influence of cognitive control and mismatch on the N2 component of the ERP: a review[J]. Psychophysiology, 2008, 45(1): 152-170.
[16] 周昕, 梁勇. 听觉事件相关电位各亚成分的起源及意义[J]. 临床耳鼻咽喉头颈外科杂志, 2008, 22(22): 1053-1056.
  Zhou X, Liang Y. The origins and significance of various subcomponents of auditory event-related potentials[J]. Linchuang Erbiyanhou Toujing Waike Zazhi, 2008, 22(22): 1053-1056.
[17] Tsai ML, Hung KL, Tao-Hsin Tung W, et al. Age-changed normative auditory event-related potential value in children in Taiwan[J]. J Formos Med Assoc, 2012, 111(5): 245-252.
[18] Kamita MK, Silva LAF, Magliaro FCL, et al. Auditory Event Related Potentials in children with autism spectrum disorder[J]. Int J Pediatr Otorhinolaryngol, 2021, 148: 110826.
[19] Kihara M, Hogan AM, Newton CR, et al. Auditory and visual novelty processing in normally-developing Kenyan children[J]. Clin Neurophysiol, 2010, 121(4): 564-576.
[20] Bakhtadze S, Khachapuridze N, Geladze N. Event related potentials in children with internet addiction disorder[J]. Eur Psychiatry, 2021, 64(Suppl 1): S88.
[21] Tao M, Sun J, Liu S, et al. An event-related potential study of P300 in preschool children with attention deficit hyperactivity disorder[J]. Front Pediatr, 2024, 12: 1461921.
[22] 接惠群, 舒文卓, 高德坤, 等. 儿童眩晕对认知功能影响的临床研究[J]. 临床儿科杂志, 2024, 42(12): 1015-1020.
  Jie HQ, Shu WZ, Gao DK, et al. Clinical study on the influence of vertigo on cognitive function in children[J]. Linchuang Erke Zazhi, 2024, 42(12): 1015-1020.
[23] Ma X, Shen J, Sun J, et al. P300 event-related potential predicts cognitive dysfunction in patients with vestibular disorders[J]. Biomedicines, 2023, 11(9): 2365-2365.
[24] Santos Filha VAVD, Bruckmann M, Garcia MV. Short- and long-latency auditory evoked potentials in individuals with vestibular dysfunction[J]. CoDAS, 2018, 30(2): e20160260.
[25] Matas CG, Silva SM, Wen DDM, et al. Auditory evoked potentials in peripheral vestibular disorder individuals[J]. Arquivos Int Otorrinolaringol, 2011, 15(3): 308-313.
[26] Zhong R, Li M, Chen Q, et al. The P300 event-related potential component and cognitive impairment in epilepsy: a systematic review and meta-analysis[J]. Front Neurol, 2019,10: 943.
[27] Casali RL, Amaral MI, Boscariol M, et al. Comparison of auditory event-related potentials between children with benign childhood epilepsy with centrotemporal spikes and children with temporal lobe epilepsy[J]. Epilepsy Behav, 2016, 59: 111-116.
Options
Outlines

/

〈 〉

Website Copyright © 2018 Journal of Clinical Pediatrics.
Tel: 021-25076489　E-mail: jcperke@126.com
Powered by Beijing Magtech Co. Ltd