Original Article

Establishment of an age-latency function model for wave Ⅴ of bone-conduction click-evoked auditory brainstem responses in normal-hearing infants and young children

  • MA Xiaobao ,
  • SHEN Jiali ,
  • WANG Wei ,
  • WANG Lu ,
  • LOU Gaozhong ,
  • ZHAO Zhehong ,
  • JIN Yulian ,
  • YANG Jun ,
  • CHEN Jianyong ,
  • QIN Huan
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  • 1. Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Translational Medicine of Ear and Nose Disease, Shanghai 200092, China
    2. Department of Otolaryngology, Hangzhou Maternity and Child Health Care Hospital, Hangzhou Children’s Hospital, Hangzhou 310000, Zhejiang, China
    3. Department of Otolaryngology, Shaoxing Central Hospital, Shaoxing 312030, Zhejiang, China

Received date: 2025-07-10

  Accepted date: 2025-09-01

  Online published: 2025-11-28

Abstract

Objective To construct latency-age function curves of waveⅤin bone-conducted auditory brainstem responses (BC-ABR) across different ages in normal-hearing infants and young children, thereby providing a reference for clinical assessment of BC-ABR thresholds. Methods Infants and young children with normal hearing who visited the Hearing Impairment and Vertigo Diagnosis and Treatment Center from January 2019 to December 2022 were selected as the research subjects. BC-ABRs were recorded at two stimulus intensities (30 dB nHL and threshold level) using click stimuli. The age-latency function model of infants and young children with normal hearing was established, and the Bland-Altman method was used to verify the model. Results A total of 210 infants and young children (410 ears) were included during the study period, including 113 boys (222 ears) and 97 girls (188 ears), with a median age of 5 (3-8) months. Among them, there were 126 ears in the 0-3 months age group, 168 ears in the 4-6 months age group, 66 ears in the 7-12 months age group, and 50 ears in the 13-36 months age group. Significant differences in wave Ⅴ latency were observed among different age groups under both 30 dB nHL and threshold stimulation (P<0.05). The latency-age function model at 30 dB nHL was: Y1=7.227+2.563×e-0.1596×x, with R2=0.44, and at threshold intensity: Y2=8.171+2.739×e-0.1432×x, with R2=0.33, where x is age in months. Bland-Altman analysis showed that the proportions of differences between measured and predicted values falling outside the 95% limits of agreement were 3.6% (4/110) and 2.7% (3/110), respectively. Conclusions Wave Ⅴ latency of BC-ABR shortens progressively with increasing age in infants and young children. The latency-age function models established in this study may serve as useful references for clinical applications.

Cite this article

MA Xiaobao , SHEN Jiali , WANG Wei , WANG Lu , LOU Gaozhong , ZHAO Zhehong , JIN Yulian , YANG Jun , CHEN Jianyong , QIN Huan . Establishment of an age-latency function model for wave Ⅴ of bone-conduction click-evoked auditory brainstem responses in normal-hearing infants and young children[J]. Journal of Clinical Pediatrics, 2025 , 43(12) : 933 -939 . DOI: 10.12372/jcp.2025.25e0803

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