Journal of Clinical Pediatrics >
Molecular mechanisms, diagnosis, and treatment of skin disorders associated with CARD14 mutations
Received date: 2025-12-16
Accepted date: 2026-03-20
Online published: 2026-05-08
In recent years, with advances in molecular biology and genetics, the CARD14 gene has been confirmed to be closely related to a variety of diseases. Patients typically develop symptoms shortly after birth, which severely impacts their health and quality of life. Due to the large clinical heterogeneity of this group of diseases and the difficulty in treatment, early identification and personalized intervention have significant clinical significance. This article systematically expounds the molecular mechanism, clinical phenotype spectrum and the latest progress of targeted therapy of CARD14-related skin diseases, aiming to provide theoretical basis and clinical reference for the precise diagnosis and treatment of such diseases.
Key words： CARD14; molecular mechanism; child
ZHAO Xinrong , XU Zigang . Molecular mechanisms, diagnosis, and treatment of skin disorders associated with CARD14 mutations[J]. Journal of Clinical Pediatrics, 2026 , 44(5) : 399 -404 . DOI: 10.12372/jcp.2026.25e1600
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