Expression of STAT3 in children with focal cortical dysplasias type IIIa

  • LOU Yan ,
  • WU JIANG ,
  • LI Wenling ,
  • WANG Jiangya
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  • 1.Hebei Medical University, Shijiazhuang 050017, Hebei, China; 2. Hebei General Hospital, Shijiazhuang 050051, Hebei, China

Received date: 2014-09-15

  Online published: 2014-09-15

Abstract

 Objectives To detect the expression of STAT3 in children with FCD (focal cortical dysplasias) type IIIa. Methods The expression of STAT3 and P-STAT3 (ser727) were determined in temporal lobe specimens from 26 children with FCD type IIIa and from 5 normal control by immunohistochemistry, immunofluorescence and Western blot. Results The expression of P-STAT3 (ser727) was obviously higher in FCD type IIIa than in control group. P-STAT3 (ser727) was located mainly in the nucleus of astrocytes. Conclusions Activated STAT3 might contribute to the patholgenesis of FCD type IIIa by mediating proliferation of astrocytes.

Cite this article

LOU Yan , WU JIANG , LI Wenling , WANG Jiangya . Expression of STAT3 in children with focal cortical dysplasias type IIIa[J]. Journal of Clinical Pediatrics, 2014 , 32(9) : 859 . DOI: 10.3969 j.issn.1000-3606.2014.09.015

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