Retrospective analysis the long-term retention rate of levetiracetam mono or combination therapy of infant epilepsy

  • FENG Xuefei ,
  • CHEN Yuxia ,
  • XIANG Shang ,
  • XIAO Nong ,
  • LIU Ling
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  • Department of Children Rehabilitation, Children’s Hospital of Chongqing Medical University, Key Laboratory of Developmental Diseases in Childhood Ministry of Education, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China

Received date: 2014-07-15

  Online published: 2014-07-15

Abstract

Objective To analysis the long-term retention rate of Levetiraceram (LEV) monotherapy or combination therapy of infant epilepsy. Methods The clinical data of patients with infant epilepsy treated by LEV had been retrospectively analyzed from July 2006 to June 2007. Results Sixty patients with infant epilepsy treated by LEV had been recruited, 20 cases with partial seizures, 19 cases with generalized seizures, 21 cases with epilepsy syndrome. Among them 21 cases was intractable epilepsy. The retention rates of LEV in 6-month, 1-year, 2-year, 3-year and 4-year were 95.5%, 75.0%, 60.0%, 51.7%, and 38.3%. The most common reason for withdrawal was lack of effect (43.2%). COX regression model suggested that duration > 1 month (RR=2.91, 95% CI: 1.16~7.30) and refractory epilepsy (RR=2.30, 95% CI: 1.22~4.32) were risk factors of withdrawal (all P<0.05). After treatment, the seizure frequency significantly reduced compared with baseline (P<0.01). To the end of the follow-up, the efficiency was 100% and the complete remission rate was 69.57% in 23 cases continued treatment. The main side effect were fatigue (56.0%), and sleep increased, irritability, and so on. Conclusions LEV monotherapy or combination therapy has well long-term retention rate, maintains well efficacy and tolerability in infant epilepsy.

Cite this article

FENG Xuefei , CHEN Yuxia , XIANG Shang , XIAO Nong , LIU Ling . Retrospective analysis the long-term retention rate of levetiracetam mono or combination therapy of infant epilepsy[J]. Journal of Clinical Pediatrics, 2014 , 32(7) : 633 . DOI: 10.3969 j.issn.1000-3606.2014.07.009

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