Expression of 4-1BB and lymphocyte subsets in peripheral blood of children with acute infectious lymphocytosis

  • FU Qiang ,
  • FENG Qihua ,
  • TANG Linfei ,
  • LI Aimin ,
  • SONG Xiaoxiang ,
  • YU Konggui
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  • 1. Department of Pediatrics, Jingzhou Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Jingzhou 434000, Hubei, China; 2. Department of Nephrology Immunity, Children's Hospital Affiliated to Soochow University, Soochow 215003, Jiangsu, China

Received date: 2014-10-15

  Online published: 2014-10-15

Abstract

Objective To investigate expression of 4-1BB and lymphocyte subsets in peripheral blood of children with acute infectious lymphocytosis. Methods Flow cytometry (FCM) was applied to detect the expression of 4-1BB and lymphocyte subsets in peripheral blood of 15 cases of acute infectious lymphocytosis and 20 cases of acute upper respiratory infection, and 20 healthy children. Results The expression of 4-1BB and CD3+, CD4+ and CD8+ lymphocytes were higher in acute infectious lymphocytosis group than those in acute upper respiratory infection group and healthy control group (P<0.05). There was no significant difference of CD19+CD23+ lymphocytes among three groups (P>0.05). A positive correlation was found between 4-1BB expression and CD3+ lymphocytes expression in acute infectious lymphocytosis group (r=0.73, P<0.05). Conclusions The abnormal expression of 4-1BB may play a pathological role in the development of acute infectious lymphocytosis. T cells in children with acute infectious lymphocytosis may not function to activate B cells.

Cite this article

FU Qiang , FENG Qihua , TANG Linfei , LI Aimin , SONG Xiaoxiang , YU Konggui . Expression of 4-1BB and lymphocyte subsets in peripheral blood of children with acute infectious lymphocytosis[J]. Journal of Clinical Pediatrics, 2014 , 32(10) : 928 . DOI: 10.3969 j.issn.1000-3606.2014.10.008

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