A case-control study about the preventive effect of magnesium sulfate on hypertention caused by ACTH in the treatment of infantile spasms

  • LIU Xiuguo ,
  • SHI Xiuyu ,
  • JU Jun ,
  • LI Jiuwei ,
  • ZOU Liping
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  • 1.Children’s Medical Center of PLA General Hospital,Beijing 100853,China; 2.Department of Pediatrics,Peoele’s Hospital, Xingtai 054001, Hebei, China; 3.Department of Neurology, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing 100045,China

Received date: 2014-11-15

  Online published: 2014-11-15

Abstract

Objective To examine the preventive effect of magnesium sulfate on hypertension caused by ACTH in the treatment of infantile spasms (IS). Methods 46 children diagnosed as IS were recruited from two hospitals during May, 2011 to October, 2013.23 patients in group A (treatment group) were treated with magnesium sulfate and ACTH in hospital A;another 23 cases in group B (control group) were treated with ACTH only in hospital B. The therapy course was 2 weeks. Results Hypertension was not observed in the treatment group, while 6 children were observed with hypertension in the control group. There was significant difference between the two groups (P<0.05). Conclusions Magnesium sulfate could prevent the incidence of hypertension in the treatment of IS with ACTH, and benefit the completion of treatment course.

Cite this article

LIU Xiuguo , SHI Xiuyu , JU Jun , LI Jiuwei , ZOU Liping . A case-control study about the preventive effect of magnesium sulfate on hypertention caused by ACTH in the treatment of infantile spasms[J]. Journal of Clinical Pediatrics, 2014 , 32(11) : 1013 . DOI: 10.3969 j.issn.1000-3606.2014.11.004

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