Food protein-induced enterocolitis syndrome caused by cow's milk protein allergy in an infant: case report and review of literature

  • Fang Tiefu ,
  • Gong Sitang ,
  • Chen Peiyu ,
  • Xu Zhaohui ,
  • Liang Cuiping ,
  • He Waner ,
  • Yang Min ,
  • Geng Lanlan ,
  • Li Huiwen
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  • Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou 510623,Guangdong, China

Received date: 2014-11-15

  Online published: 2014-11-15

Abstract

To discuss clinical diagnosis and treatment of cow’s milk protein allergy and cow’s milk protein-induced FPIES (food protein induced enterocolitis syndrome). Methods We retrospectively analyzed clinical data of one infant with milk protein allergy-induced FPIES. Results A 67 days old female on mixed breast and formula feeding developed recurrent diarrhea, abdominal distension, vomiting, mucousy and bloody stools, feeding difficulty, anemia, and failure to thrive since 2 weeks after birth. Laboratory studies showed anemia, increased CRP level and elevation of peripheral white blood count and eosinophil proportion. Milk-specific IgE was negative. She was previously hospitalized 4 times, all with admitting diagnosis of “necrotizing enterocolitis”. We treated her with milk protein elimination for 4 weeks and all symptoms were resolved. Milk protein rechallenge test was positive, consistent with clinical features of cow’s milk protein allergy-induced infant FPIES. Conclusions Cow’s milk protein allergy and cow’s milk protein-induced FPIES can present with non-specific and variable clinical symptoms and signs, and should be considered in the differential diagnosis.

Cite this article

Fang Tiefu , Gong Sitang , Chen Peiyu , Xu Zhaohui , Liang Cuiping , He Waner , Yang Min , Geng Lanlan , Li Huiwen . Food protein-induced enterocolitis syndrome caused by cow's milk protein allergy in an infant: case report and review of literature[J]. Journal of Clinical Pediatrics, 2014 , 32(11) : 1072 . DOI: 10.3969 j.issn.1000-3606.2014.11.018

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