Research progress of fecal and urinary biomarkers for early diagnosis of neonatal necrotizing enterocolitis

  • LUO Lijuan ,
  • LI Luquan
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  • Department of Neonatalogy, Children's Hosiptal of Chongqing Medical University, Chongqing 400014, China

Received date: 2014-11-15

  Online published: 2014-11-15

Abstract

Necrotizing enterocolitis (NEC) is the most common severe gastrointestinal emergency in neonatal period. Searching biomarkers to identify infants at greatest risk of developing NEC might be of importance for early diagnosis, effective treatment and better prognosis of NEC. Biomarkers from stool and urine attract great attention due to non-invasiveness and easy availability of fecal and urinary sampling. This article reviews the latest research progress of non-invasive biomarkers including intestinal fatty acid binding protein, serum amyloid A, complement C3a and C5a in urine; fecal lactoferrin, intestinal bacteria spectrum, fecal calprotectin, S100A12 and high mobility group box-1 protein.

Cite this article

LUO Lijuan , LI Luquan . Research progress of fecal and urinary biomarkers for early diagnosis of neonatal necrotizing enterocolitis[J]. Journal of Clinical Pediatrics, 2014 , 32(11) : 1089 . DOI: 10.3969 j.issn.1000-3606.2014.11.022

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