Advances in research of the relationship between adhesion molecules and pathogenesis of Kawasaki disease

  • CHAO Lumen ,
  • CHEN Baiyu
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  • Derpartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China

Received date: 2014-12-15

  Online published: 2014-12-15

Abstract

Adhesion molecules (AM) are a class of molecules that can mediate cell-to-cell and cell-to-matrix interaction. They participate in the cellular recognition, signal transduction, cell proliferation and differentiation, cell stretching and movement through ligand-to-receptor interaction. AM are the molecular basis of immune response, inflammation, blood coagulation, tumor metastasis, wound healing and a series of physiological and pathological processes. Kawasaki disease (KD) is an acute systemic small vasculitis syndrome, mainly affecting coronary artery. KD is the main cause for acquired heart disease in children. To study the relationship between AM and pathogenesis of KD is important in the understanding of KD pathogenesis, prevention and treatment of coronary artery lesions complicated with KD. This review focused on the relationship between AM and pathogenesis of KD.

Cite this article

CHAO Lumen , CHEN Baiyu . Advances in research of the relationship between adhesion molecules and pathogenesis of Kawasaki disease[J]. Journal of Clinical Pediatrics, 2014 , 32(12) : 1194 . DOI: 10.3969 j.issn.1000-3606.2014.12.023

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