Diagnostic value of urine S-100B protein levels in brain injury in premature infants

  • LU Jihong ,
  • BAO Xingxing ,
  • JIN Yue ,
  • JIN Quan ,
  • HE Zhen ,
  • XIAO Mei ,
  • WANG Fen ,
  • TANG Hanhong ,
  • ZHANG Min
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  • Department of Pediatrics, The Third Hospital of Wuhan, Wuhan 430074, Hubei, China

Received date: 2015-01-15

  Online published: 2015-01-15

Abstract

 Objective To investigate the diagnostic value of urine S-100B protein levels in brain injury in premature infants. Methods A total of 76 premature infants with gestational age less than 35 weeks were selected from January to December 2012. Urine samples were obtained at 24 h, 72 h and 120 h after birth, and S-100B protein levels in urine were detected by chemiluminescence. According to the results of cranial ultrasound and MRI, all infants were divided into periventricular leukomalacia (PVL) group (n=16), periventricular-intraventricular haemorrhage (PVH-IVH) group (n=20) and no brain injury group (control group) (n=40). Urine S-100B protein levels were compared among groups. Results There was significant difference in Urine S-100B protein levels among PVL, PVH-IVH and control groups at 24 h, 72 h and 120 h after birth (P<0.01). At each time point, the urine S-100B protein levels were highest in PVL group and lowest in control group, and the differences were significant (P<0.01). The urine S-100B protein levels were significantly different among different time points in PVL and PVH-IVH groups (P<0.01), reaching a peak at 72 h and starting to decrease at 120 h. Conclusions Urine S-100B protein can be used as a sensitive indicator of brain injury in judging disease severity and assessing prognosis.

Cite this article

LU Jihong , BAO Xingxing , JIN Yue , JIN Quan , HE Zhen , XIAO Mei , WANG Fen , TANG Hanhong , ZHANG Min . Diagnostic value of urine S-100B protein levels in brain injury in premature infants[J]. Journal of Clinical Pediatrics, 2015 , 33(1) : 44 . DOI: 10.3969 j.issn.1000-3606.2015.01.011

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