The research progress of GATA6 in heart development and isolated atrial septal defect

XU Xicai; LI Fen; ZHOU Wanping; ZHU Diqi; JI Wei; HU Jingjing; CHEN Yiwei; QIAN Yijiao; DAI Ke

doi:10.3969 j.issn.1000-3606.2015.04.022

Journal of Clinical Pediatrics >

2015 , Vol. 33 >Issue 4: 380

DOI: https://doi.org/10.3969 j.issn.1000-3606.2015.04.022

The research progress of GATA6 in heart development and isolated atrial septal defect

XU Xicai ,
LI Fen ,
ZHOU Wanping ,
ZHU Diqi ,
JI Wei ,
HU Jingjing ,
CHEN Yiwei ,
QIAN Yijiao ,
DAI Ke

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Department of Pediatric Cardiology, Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Received date: 2015-04-15

Online published: 2015-04-15

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Abstract

GATA6 transcription factor belongs to the GATA family and contains 2 conserved zinc finger DNA binding domains. GATA6 not only presents in embryonic tissues but also found in heart, lung and pancreas and is essential for the maintenance of their function.The present review focuses on the critical roles of GATA6 in heart development and atrial septal defect to provide theoretical basis for diagnosis and treatment of atrial septal defect.

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XU Xicai , LI Fen , ZHOU Wanping , ZHU Diqi , JI Wei , HU Jingjing , CHEN Yiwei , QIAN Yijiao , DAI Ke . The research progress of GATA6 in heart development and isolated atrial septal defect[J]. Journal of Clinical Pediatrics, 2015 , 33(4) : 380 . DOI: 10.3969 j.issn.1000-3606.2015.04.022

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