Analysis of polymorphism of mTOR gene in children with leukemia 

  • XIONG Hao ,
  • ZHAO Peiwei ,
  • YUE Xin ,
  • LI Hui ,
  • HE Xuelian ,
  • LI Jianxin
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  • Wuhan Children’s Hospital, Wuhan 430016, Hubei, China

Received date: 2015-05-15

  Online published: 2015-05-15

Abstract

Objective To investigate the association of single nucleotide polymorphism (rs2295080) in mTOR gene with the susceptibility to acute leukemia (AL) in Chinese children. Methods A case-control study was performed by recruitment of 180 children with AL and 296 healthy children as controls. The genotype of this SNP was detected using PCR-RFLP. The data were analyzed by SPSS19.0. Results There was a significant difference in genotypes in three groups (ALL, AML and control) (P=0.026). And the SNP was associated with AL, with G allele being higher in AL group than that in controls (OR=1.413, 95%CI: 1.050-1.901, P=0.022). In ALL group, G allele was also higher than that in healthy group (OR=1.456, 95%CI: 1.052-2.015, P=0.023). However, no significant association was observed in AML patients (P=0.302). In addition, ALL patients with GG genotype were associated with disease severity compared with patients with TT or GT genotype (OR=2.044, 95%CI: 0.569-7.341). Conclusion The rs2295080 was associated with ALL, with G allele being a risk factor.

Cite this article

XIONG Hao , ZHAO Peiwei , YUE Xin , LI Hui , HE Xuelian , LI Jianxin . Analysis of polymorphism of mTOR gene in children with leukemia [J]. Journal of Clinical Pediatrics, 2015 , 33(5) : 423 . DOI: 10.3969 j.issn.1000-3606.2015.05.006

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