Expression of plasma microRNA-223 and HMGB-1 in pediatric sepsis patients and its clinical significance

  • DONG Yanfei ,
  • LIANG Guilin ,
  •  LIU Caili ,
  • LU Lingli ,
  • GUO Yingxia
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  • The maternal and Child Health Hospital of Qingyuan City,Guangdong Province, Qingyuan 511500, Guangdong, China

Received date: 2015-05-15

  Online published: 2015-05-15

Abstract

Objective To investigate the changes of plasma microRNA-223(miR-223) and HMGB-1 in pediatric sepsis patients. Methods There were 49 children with sepsis enrolled in the study (sepsis group),severe sepsis group (n=25) and general group (n=24). Meanwhile, 50 healthy children (normal control group) were selected as control group. The expression levels of plasma miR-223and HMGB-1 (high mobility group box 1) were detected. The predictive values of miR-223and HMGB-1 in plasma of children with sepsis were evaluated by receiver operatingcharacteristic (ROC) curve. Results The plasma miR-223 and HMGB-1 expression levels in severe sepsis group and general group were up-regulated compared with those in the normal control group (F=63.02, 76.32, P<0.05). The area under ROC curve of miR-223,HMGB-1 predicting sepsis were 0.904 (95%CI 0.821-0.998), 0.748 (95%CI: 0.625-0.903). There was positive correlation between miR-223 and HMGB-1 (r=3.532, P<0.05). Conclusions The expression levels of plasma miR-223 in children with sepsis are significantly up-regulated, which can be used as early diagnostic markers to reflect the severity of inflammation in some degree.

Cite this article

DONG Yanfei , LIANG Guilin ,  LIU Caili , LU Lingli , GUO Yingxia . Expression of plasma microRNA-223 and HMGB-1 in pediatric sepsis patients and its clinical significance[J]. Journal of Clinical Pediatrics, 2015 , 33(5) : 459 . DOI: 10.3969 j.issn.1000-3606.2015.05.015

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