Abnormal activation of Notch1 and T-cell acute lymphoblastic leukemia

  • YAN Hui ,
  • MO Xi ,
  • LIU Lanbo
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  • Pediatric Institute of Translational Medicine, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127,China)

Received date: 2015-05-15

  Online published: 2015-05-15

Abstract

Abnormal activation of Notch1 plays pivotal roles in the molecular pathogenesis of human T-cell acute lymphoblastic leukemia (T-ALL). Activating Notch1 mutations present in over 60% of the T-ALL patients. However, so far, there is no therapy with little side effects that specifically targets the abnormally activated Notch1 pathway-induced T-ALL. The present study briefly reviewed the effects of abnormal activation of Notch1 in the pathogenesis of T-ALL, as well as the current approaches targeting Notch1 and its limitations, thus providing some guidance for the research and development of clinical therapies targeting T-ALL.

Cite this article

YAN Hui , MO Xi , LIU Lanbo . Abnormal activation of Notch1 and T-cell acute lymphoblastic leukemia[J]. Journal of Clinical Pediatrics, 2015 , 33(5) : 483 . DOI: 10.3969 j.issn.1000-3606.2015.05.021

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