Autophagy is the process that cells degradate the damaged organelles and the macromolecules by lysosomes. It is a phenomenon of life which is widely existed in nature and plays an important role in maintaining the stability of cellular structure. Current studies showed that the PI3K/Akt signaling pathway, which involved in multiple physiological and pathological processes, is one of the important signaling pathways of autophagy. Recent studies found that the levels of podocyte autophagy and the podocyte diseases have close relationship with PI3K/Akt signaling pathway. In this article, the relationship between autophagy and the PI3K/Akt pathway will be reviewed.