Changes of surfactant protein-D in serum and cerebrospinal fluid in children with viral encephalitis

  • WANG Wenjuan ,
  • WANG Xueyu
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  • Department of Pediatrics, Shandong Provincial Hospital Affiliated Shandong University, Jinan 250021,Shandong, China

Received date: 2015-06-15

  Online published: 2015-06-15

Abstract

Objective To investigate the changes of the pulmonary surfactant protein-D (SP-D) in serum and cerebrospinal fluid in children with viral encephalitis (VE). Methods The levels of SP-D in serum and cerebrospinal fluid were detected by a double-antibody sandwich enzyme-linked immunosorbent assay and compared in thirty children with VE in acute and convalescent phases and in 12 children without VE. Results The levels of SP-D in serum and cerebrospinal fluid between groups of VE acute phase and convalescent phase and no VE were statistically significant (F=103.58,118.15, all P<0.01). The levels of SP-D in serum and cerebrospinal fluid in children with VE in acute phase and in convalescent phase were significantly lower than children without VE (P<0.01). The levels of SP-D in serum and cerebrospinal fluid in children with VE in convalescent phase were all significantly higher than those in acute phase (P<0.01). In children with VE, the level of SP-D in cerebrospinal fluid was weakly correlated negatively with the count of nucleated cells. Conclusions SP-D might be involved in the pathogenesis in VE. The detection of SP-D in serum and cerebrospinal fluid has a certain value for diagnosis of VE.

Cite this article

WANG Wenjuan , WANG Xueyu . Changes of surfactant protein-D in serum and cerebrospinal fluid in children with viral encephalitis[J]. Journal of Clinical Pediatrics, 2015 , 33(6) : 535 . DOI: 10.3969 j.issn.1000-3606.2015.06.009

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