Objectives　To explore the clinical manifestations and treatment of Mycoplasma pneumoniae pneumonia (MPP) combined with venous thrombosis. Methods　The clinical manifestations and treatment of MPP combined with venous thrombosis were retrospectively analyzed. Results　Two male patients were 5 years 2 months and 3 years 6 months old respectively. After treatment with erythromycin, corticosteroids, immunoglobulin, bronchoalveolar lavage and thrombolytic, both cases were cured. Conclusions It is necessary to pay attention to the occurrence of thrombosis in MPP. Early diagnosis and treatment of thrombosis is very important for the prognosis. The prevention of thrombosis needs to be further studied.