Diagnostic value of N-terminal pro-brain natriuretic peptide and MB isoenzyme of creatine kinase for heart failure in pneumonia children 

  • JIA Xiuhong ,
  • TANG Shenhua ,
  • ZHANG Yanyan ,
  • LI Jianchang ,
  • LI Xiaomei
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  • Department of Pediatrics, Binzhou Medical University Hospital, Binzhou 256603, Shandong, China

Received date: 2015-08-15

  Online published: 2015-08-15

Abstract

 Objective To investigate the diagnostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and MB isoenzyme of creatine kinase (CK-MB) for heart failure (HF) in pneumonia children. Methods The NT-proBNP and CKMB were assayed in 132 pneumonia children with HF, 138 pneumonia children without HF and 62 healthy children were recruited into this study. A receiver operating characteristics (ROC) curve and a logistic regression model were employed to assess the diagnostic accuracy of NT-proBNP and CK-MB for HF in pneumonia children. Results Pneumonia children with HF had higher blood NT-proBNP and CK-MB than those in pneumonia children without HF and healthy controls (P<0.01 for both). Pneumonia children with HF had higher blood NT-proBNP and CK-MB than the pneumonia children without HF. The area under curves (AUCs) of NT-proBNP and CK-MB for HF were 0.85 and 0.72, respectively. The AUC for their combinational usage was 0.87. Conclusion Both NT-proBNP and CK-MB are effective markers as diagnostic adjuncts for HF in pneumonia children. Combination of NT-proBNP and CK-MB can improve the diagnostic accuracy for HF in pneumonia children.

Cite this article

JIA Xiuhong , TANG Shenhua , ZHANG Yanyan , LI Jianchang , LI Xiaomei . Diagnostic value of N-terminal pro-brain natriuretic peptide and MB isoenzyme of creatine kinase for heart failure in pneumonia children [J]. Journal of Clinical Pediatrics, 2015 , 33(8) : 694 . DOI: 10.3969 j.issn.1000-3606.2015.08.004

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