Objective 　To analyze the potential risk factors for relapse and development of epilepsy in patients with benign infantile convulsions associated with mild gastroenteritis (BICE). Methods　A total of 264 cases of BICE were recruited. According to the frequency of convulsions, the patients were divided into single group (n=134, convulsion once), and multiple group (n=130, convulsions ≥ 2 times). According to convulsion duration, the patients were divided into short-term group (n=186, convulsions duration <5 minutes) , and long-term group (n=78, convulsion duration ≥ 5 minutes). The clinical data obtained during hospitalization and follow-up were analyzed. Results　In multiple group, 9.23% were relapsed and 6.15% developed epilepsy. In single group, 2.99% were relapsed and 0.75% developed epilepsy. There were significantly different in the rate of relapses and development of epilepsy between two groups (P<0.05). In the long-term group, 12.82% were relapsed and 8.97% developed epilepsy. In the short-term group, 3.23% were relapsed and 1.08% developed epilepsy. There were significantly different in the rate of relapses and development of epilepsy between the two groups (P<0.05). Conclusions　There are the risks of relapse and development of epilepsy in BICE patients. Convulsions ≥ 2 times and ≥ 5 minutes may be the risk factors of relapse and development of epilepsy.