eNOS gene G10T polymorphism in 1290 children with sporadic congenital heart disease

  • QIN Yuming ,
  • MO Xuming ,
  • ZHOU Kai
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  • Department of Cardiology, Affiliated Children’s Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu, China

Received date: 2015-09-15

  Online published: 2015-09-15

Abstract

Objective To investigate the association between endothelial NO synthase (eNOS) gene G10T polymorphism nd the susceptibility of sporadic congenital heart disease (CHD). Methods The genotype on eNOS G10T locus was detected nd compared in 1323 children with sporadic CHD and 1323 non-CHD children. Results Compared with the CC genotype, the A genotype significantly increased the risk of CHD (adjusted OR=1.42, 95% CI=1.01-2.04). Compared with the CC/AC genotype, he AA genotype significantly increased the risk of CHD (adjusted OR=1.39, 95% CI=1.08-1.92). Based on stratified analysis, he AA genotype was associated with the susceptibility of perimembranous ventricular septal defects (adjusted OR=1.56, 95% CI=1.17-2.47). Conclusions In Chinese population, the eNOS G10T polymorphism may increase the susceptibility of sporadic CHD.

Cite this article

QIN Yuming , MO Xuming , ZHOU Kai . eNOS gene G10T polymorphism in 1290 children with sporadic congenital heart disease[J]. Journal of Clinical Pediatrics, 2015 , 33(9) : 807 . DOI: 10.3969 j.issn.1000-3606.2015.09.011

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