Recent years, there is a great advance in the diagnosis and treatment of epilepsy, but there are still some kinds of epilepsy syndrome proven difficult to diagnose and manage for unknown etiology. Among etiologies, genetic factors are under intense study. Studies suggested that multiple epilepsy syndromes are correlated to chromosome 15 (15q), including Angelman syndrome, infantile spasms, childhood absence epilepsy, and so on. This article summarizes the research progress in the diagnosis and treatment of epilepsy as described above, expecting to give input for the new thoughts of clinics and research.