Objective　To summarize the clinical features of Pseudomonas aeruginosa sepsis in children. Methods　We retrospectively review the clinical data of a baby boy with Pseudomonas aeruginosa sepsis and summarize its clinical characteristics. Results　A ten-month male infants with onset symptom of fever, irritability, drowsiness, cough and sputum was diagnosed as Pseudomonas aeruginosa sepsis through blood and sputum culture. The baby recovered well after anti-infection treatment. Conclusions　Timely and appropriate use of sensitive antibiotics can decrease severe complications and mortality rate of Pseudomonas aeruginosa sepsis in children.